Observation On The Curative Effect Of Combined Traditional Chinese And Western Medicine Sequential Optimization Scheme In The Treatment Of Plaque Psoriasis

Objective: Based on the clinical experience of "new blood demonstration",this study adopts the combination of traditional Chinese and western medicine to treat plaque psoriasis objectively,evaluates its clinical efficacy,safety and recurrence objectively,and forms and optimizes plaque psoriasis The standard of sequential diagnosis and treatment of combined traditional Chinese and western medicine.Methods: A randomized,single-blind,controlled experimental design type was used to select patients with plaque psoriasis(10%BSA≤15%)who met the inclusion criteria in the dermatology clinic of the Affiliated Chinese Medicine Hospital of Southwest Medical University(after calculation of the sample size,this The sample size undertaken by the research center was 54cases),and they were divided into a traditional Chinese medicine treatment group,a western medicine treatment group,and an integrated traditional Chinese and western medicine treatment group according to the random number method(18 cases in each group).On the basis of external use of Yuze skin barrier repairing body lotion,the Chinese medicine treatment group was given oral Jueyin granules,taking a cup and NB-UVB placebo,while the western medicine treatment group was given Jueyin granules placebo,cupping placebo and NB-UVB.The treatment group was treated with Jueyin granules,cupping and NB-UVB for 8 weeks.Follow-up was conducted at 0,2,4,6,and8 weeks of treatment,and the patients’ skin lesion area and severity index score(PASI),skin lesion area score(BSA),pruritus symptom self-assessment score(VAS),and physician’s subjective symptoms were recorded.Score(PGA),quality of life score(DLQI)level and follow-up after treatment.SPSS26.0 was used for statistical analysis to compare the clinical efficacy and recurrence of the three groups.The safety was evaluated by the changes of vital signs,laboratory tests and adverse reactions before and after treatment,during treatment.Results:(1)In the traditional Chinese medicine treatment group,16 cases were completed,and 2 cases were dropped;17 cases were completed in the western medicine treatment group,and 1 case was dropped;The three groups of patients were comparable in terms of gender,age,course of disease and other general data and the scores of PASI,BSA,VAS,PGA and DLQI before treatment,P>0.05.(2)Efficacy: The PASI,VAS,PGA,and DLQI scores of the three groups of patients decreased with the increase of medication time(P<0.05);the BSA score did not change significantly(P>0.05).Comparing the four scores of PASI,VAS,PGA and DLQI among the four groups,the integrative traditional Chinese and Western medicine treatment group showed the most significant downward trend in all indicators,and the curative effect was the best,and the difference was statistically significant(P<0.05).Comparison: In the 2nd week of treatment,the Chinese medicine treatment group had better curative effect,and in the 4th and 6th week of treatment,the western medicine treatment group was significantly better than the Chinese medicine treatment group,and the difference was statistically significant(P<0.05);in the 8th week of treatment,the western medicine treatment group The VAS score decreased more significantly,and the difference was statistically significant(P<0.05).In terms of PASI,PGA,and DLQI scores,the two groups had similar curative effects,and the difference was not statistically significant(P>0.05).After 8 weeks of treatment,the total effective rates of the three groups: Chinese medicine treatment group(62.5%),Western medicine treatment group(64.7%),and integrated Chinese and Western medicine treatment group(93.8%).significance.(3)Recurrence and safety: Follow-up for 2 months,recurrence rate:Chinese medicine treatment group(6.3%),western medicine treatment group(17.6%),integrated Chinese and Western medicine treatment group(6.3%),comparison between groups(P<0.05),the difference Not statistically significant.There was no obvious abnormality in the vital signs and laboratory indexes in the three groups before and after treatment,and during the treatment;there was 1 adverse reaction unrelated to the drug in the western medicine treatment group during the treatment;Conclusion:(1)Sequential treatment of combined traditional Chinese and western medicine can effectively reduce(10%<BSA≤15%)PASI,VAS,and PGA scores of plaque psoriasis,and improve the quality of life of patients,but the improvement of skin lesions is not effective.Significantly.(2)The sequential treatment of plaque psoriasis(10%<BSA ≤ 15%)combined with traditional Chinese and western medicine has definite curative effect,low short-term recurrence rate and good safety,which is suitable for clinical application.