Ciinical Observation On The Effect Of Qilian Sijunzi Decoction In The Treatment Of Early Diabetic Kidney Disease In Elderly Patients With Spleen-Kidney Deficiency Type

Objective: To explore the Effect of Qilian Sijunzi Decoction in the treatment of diabetic kidney disease in elderly patients with blood stasis and deficiency of spleen and kidney,and to evaluate the safety,efficacy as well as therapeutic mechanism in clinic,with a view to offer new methods for the treatment of the diabetic kidney disease in early stage with traditional ChineseMethods: From December 2020 to January 2022,60 patients with early diabetic nephropathy of spleen-kidney deficiency and blood stasis type who met the inclusion criteria in the Internal Medicine and Miscellaneous Diseases Clinic or the geriatric ward of the First Affiliated Hospital of Shandong University of Traditional Chinese Medicine were screened.According to the principle of randomization,they were divided into a treatment group and a control group with 30 cases in each.The control group was given standard western medicine routine treatment,and the treatment group was given Qilian Sijunzi Decoction on the basis of the control group,and the course of treatment was 2 months.Before and after treatment,the TCM syndrome score,clinical response rate,and main laboratory indexes in the two groups were observed:(1)Urine microalbumin(U-m ALB)(2)Urine microalbumin/creatinine ratio(UACR)(3)Cystatin-C(CysC)(4)High-sensitivity C-reactive protein(hs-CRP);secondary indicators:changes in blood glucose,blood lipids,vital signs,three major routines,liver function,and electrocardiogram.SPSS 22.0 was used for statistical analysis of the above data.Results:(1)There were no significant differences in age,course of disease,gender,and various observation indicators before treatment between the two groups(P>0.05).(2)Total clinical effective rate: After treatment,the total clinical effective rate of the treatment group was 86.67%,which was significantly higher than that of the control group,which was 70.00%,and the difference was statistically significant(P>0.05).(3)Compared with before treatment,the TCM symptom scores of the two groups of patients were significantly decreased after treatment(p<0.05),and the treatment group was better than the control group(P<0.05).The difference was statistically significant.(4)Main indicators: Compared with before treatment,the levels of UACR in the two groups decreased significantly after treatment(86.99±23.71vs66.80±23.36 in the treatment group,p<0.01)(83.90±20.70 vs 78.30±20.42 in the control group,p<0.05).Compared with the control group(P<0.05).The level of U-m ALB decreased significantly after treatment(treatment group 106.67±21.56 vs 67.01±26.00,p<0.01)(control group 105.49±20.84vs81.25±23.33,p<0.05),and the treatment group was better than the control group(P<0.05).The hs-CRP level decreased(the treatment group was19.72±7.49 vs 15.87±5.89,p<0.05)(the control group was 21.40±8.71vs18.81±5.31,p<0.05),and The treatment group was better than the control group(P<0.05).The Cys-C level decreased(the treatment group 1.35±0.29vs0.87±0.26,p<0.05)(the control group 1.34±0.30 vs 1.02±0.25,p<0.05),and the treatment group was better than the control group(P<0.05).All the above differences were all statistically significant.(5)Metabolic indicators: After treatment,the levels of FPG,Hb A1 c,TG,and LDL-C in the two groups were decreased(p<0.05 or p<0.01),and the treatment group was better than the control group(P<0.05).The differences were statistically significant.(6)In this experiment,there was no obvious abnormality in the safety indicators of the two groups.Conclusion:Qilian Sijunzi Decoction is safe and effective in the treatment of spleen-kidney deficiency and blood stasis type senile early diabetic nephropathy.It can effectively relieve the clinical symptoms of patients,improve renal function,control glucose and lipid metabolism and inflammatory indicators,and has the value in further research.