Observation On The Clinical Efficacy Of Treating Low Body-weight Type PCOS Based On The Theory Of "Spleen-kidney Correlation"

ObjectiveTo observe the clinical efficacy and body composition changes of low body-weight type PCOS based on the theory of"Spleen-kidney Correlation",and to explore the efficacy of this treatment regimen,in order to provide an effective treatment for low body-weight type PCOS patients.MethodsA total of 67 valid data were included in this study,34 patients in the treatment group were treated with traditional Chinese medicine combined with lifestyle change,and 33 patients in the control group were treated with Diane 35 combined with lifestyle change.Before and after treatment,TCM symptom score,LH,FSH,E₂,T and other sex hormones and BMI,skeletal muscle standard ratio,body fat rate,WHR,basal metabolic rate and other body composition indicators were measured in the two groups.The comprehensive curative effect,TCM score,sex hormones and body composition indexes were compared between the two groups before and after treatment.Results1.There was no significant difference in age,height,TCM score,LH,FSH,LH/FSH,T,E₂,BMI,WHR,body fat rate,skeletal muscle standard ratio and basal metabolic rate before treatment between the two groups（P>0.05）,with comparability.2.Comprehensive efficacy:The two groups had significant efficacy after treatment,and the comprehensive efficacy of the treatment group was significantly better than that of the control group,and the difference had statistical significance（P<0.05）.3.TCM score:The two groups were significantly reduced after treatment,and after treatment control group decreased more significantly,the difference was statistically significant（P<0.05）.It indicated that the two groups of patients were significantly improved after treatment,and the improvement was more significant in the treatment group.4.Body composition indicators:Skeletal muscle standard ratio and basal metabolic rate in the two groups were significantly increased after treatment,and the increase in the treatment group was more significant than that in the control group,and the above differences were statistically significant（P<0.05）.BMI in the treatment group increased significantly after treatment,and the difference had statistical significance（P<0.05）.There was no significant change in the control group after treatment（P>0.05）.The body fat rate in the treatment group was significantly lower after treatment,and the difference had statistical significance（P<0.05）.There was no significant change in the control group after treatment（P>0.05）.The body fat rate of patients with high body fat in the two groups was significantly lower after treatment,and the difference was statistically significant（P<0.05）.WHR did not change significantly after treatment in both groups（P>0.05）.It indicated that both groups could significantly improve the skeletal muscle mass and basal metabolic rate of patients,and the therapeutic effect was better in the treatment group.The treatment group can increase the BMI of patients and reduce the body fat rate of patients.After treatment,the body fat rate of patients with high body fat could be reduced in both groups.5.Sex hormone levels:LH,LH/FSH,and T decreased significantly after treatment in both groups,and the difference was statistically significant（P<0.05）.FSH and E₂did not change significantly after treatment（P>0.05）.There was no significant difference in LH,LH/FSH,and T after treatment between the two groups（P>0.05）.This indicated that both groups could reduce LH,LH/FSH,and T,and the efficacy was comparable between the two groups.6.Analysis whether changes in body composition is associated with efficacy and sex hormones:The more BMI increases after treatment compared with that before treatment,the better the overall efficacy and the more the decrease in TCM score（P<0.05）.There was no correlation between the difference in BMI before and after treatment and the other parameters（P>0.05）.There was no correlation between the difference of skeletal muscle standard percentage before and after treatment and the efficacy and sex hormones（P>0.05）.Conclusion1.Under the guidance of"spleen-kidney Correlation"theory,the use of traditional Chinese medicine in the treatment of underweight PCOS patients has a significant effect,the treatment group is better than the control group.2.Under the guidance of"spleen-kidney Correlation"theory,the use of traditional Chinese medicine in the treatment of underweight PCOS can regulate LH,LH/FSH and T,BMI,skeletal muscle standard ratio,body fat rate and basal metabolic rate.3.The method of invigorating the spleen and tonifying the kidney has the effect of increasing skeletal muscle content in low body-weight type PCOS patients.4.The more the increase of BMI after treatment compared with that before treatment,the better the overall efficacy,and the more the decrease of TCM score.