| Objective By observing the clinical efficacy of Yinchen Gutai Decoction in the treatment of late threatened abortion with maternal and fetal ABO blood group incompatibility of kidney deficiency and damp-heat type,the efficacy and safety of this prescription in the treatment of this disease were evaluated in order to provide a reference for the clinical treatment of this disease in traditional Chinese medicine.MethodA total of 60 patients who visited the Department of Gynecology,Zhangzhou Hospital of Traditional Chinese Medicine,Fujian University of Traditional Chinese Medicine between January 2021 and September 2021 and met the inclusion criteria and did not meet the exclusion criteria of this study were selected.They were randomly divided into treatment group(n=30)and control group(n=30).The treatment group was treated with "Yinchen Gutai Decoction",and the control group was treated with "dydrogesterone+Vit C+Vit E" orally.Serum IgG antibody titer and TCM efficacy score were recorded before and after treatment in both groups,respectively.Statistical correlation analysis techniques were used to compare the differences in efficacy between the two treatment methods.Results1.Before treatment,there was no significant difference in age,days of menopause,number of adverse pregnancies,length of vaginal bleeding,TCM score,and serum IgG antibody titer between the two groups(P>0.05).2.Comparison of vaginal bleeding time: the symptoms of vaginal bleeding were improved after treatment in both groups,but the difference was not statistically significant(P>0.05),suggesting that the two had equivalent efficacy in controlling vaginal bleeding.3.Comparison of serum IgG antibody titer: Within the group,the serum IgG antibody titer in the treatment group was significantly lower after treatment,and the difference had statistical significance(P<0.05),indicating that Yinchen Gutai Formula could effectively reduce the serum IgG antibody titer;while the difference in the control group had no statistical significance(P>0.05),indicating that the control group had poor effect in reducing the titer.Compared with the control group,the number of patients with serum IgG antibody titer<1:64after the end of treatment in the treatment group was significantly more,and the difference was statistically significant(P<0.05),indicating that the treatment had a significant advantage in reducing serum titer.4.Comparison of the number of treatment courses: There was no significant difference in the number of treatment courses between the two groups(P>0.05),which regimen had a shorter treatment cycle cannot be explained.5.Comparison of TCM score: Within the group,the scores of the two groups after treatment were significantly lower than those before treatment,and the differences were statistically significant(P<0.05),indicating that the two groups had results in improving the clinical symptoms of TCM.There was no significant difference(P>0.05),indicating that the two regimens had equivalent efficacy in reducing the score.6.Comparison of curative effect of TCM: The effective rate was 86.6% in the treatment group and 70.0% in the control group,and the difference was statistically significant(P<0.05),indicating that the therapeutic effect of the treatment group was better than that of the control group.7.Comparison of the curative effect of maternal and fetal ABO blood group incompatibility:the effective rate was 93.3% in the treatment group and 66.7% in the control group,and the difference was statistically significant(P<0.05),indicating that the therapeutic effect of the treatment group was better than that of the control group.8.Comparison of comprehensive efficacy:the effective rate was 83.3% in the treatment group and 53.4% in the control group,and the difference had statistical significance(P<0.05),indicating that the efficacy of the treatment group was better than that of the control group.9.Adverse reactions: No adverse reactions occurred during treatment in both groups.10.Safety evaluation: The general condition,routine,liver and kidney function,coagulation function,ECG and other evaluations before and after treatment showed no abnormality in the two groups.These results indicate that the two treatment regimens selected for this study are relatively safe.ConclusionYinchen Gutai Decoction has good safety and efficacy in the treatment of late threatened abortion with maternal and fetal ABO blood group incompatibility of kidney deficiency and damp-heat type,can effectively improve the symptoms of late threatened abortion,and has achieved results in reducing serum IgG antibody titer. |
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