| Objective: The purpose of this paper is to study the use of Shaoyao decoction combined with western medicine mesalazine in the treatment of damp heat accumulation ulcerative colitis.The clinical efficacy and safety of TCM syndrome differentiation and treatment of the disease are explored by observing the improvement of TCM syndrome,quality of life and changes of intestinal mucosa under endoscopy before and after treatment,To provide basis and prove its superiority for the clinical treatment of ulcerative colitis with traditional Chinese medicine syndrome differentiation.Methods: From September 2020 to November 2021,60 patients with ulcerative colitis with damp heat accumulation syndrome differentiation were collected from the outpatient department of spleen and stomach,the outpatient department of Guoyitang and the inpatient department of the Affiliated Hospital of Jiangxi University of traditional Chinese medicine.According to the basic principle of randomization and control,60 eligible subjects who met the inclusion criteria were divided into control group and treatment group,with 30 cases in each group.The control group was treated with mesalazine enteric coated tablets(Huidi),1g / time,3 times/ day;The treatment group was treated with mesalazine enteric coated tablets combined with Shaoyao decoction.Shaoyao Decoction plus reduced formula preparation is supplied by the granule pharmacy of our hospital,one dose a day,twice a day,and take it gently half an hour after dinner.The subjects in both groups were treated for 8 weeks.After the treatment cycle,the changes of quantitative integral table of TCM syndrome,curative effect evaluation table of TCM syndrome,morphological evaluation integral table of mucosal lesions under colonoscopy and specific quality of life scale of inflammatory bowel disease in the two groups before and after treatment were observed and analyzed,and their safety was evaluated through relevant indicators.Results:1.There was no significant difference in gender,age,duration of onset and lesion location between the two groups(P > 0.05),indicating that the baseline situation of the two groups was basically the same,and this study was comparable.2.TCM syndrome: the total score of TCM syndrome after completing the medication cycle of the two groups was significantly lower than that before medication(P < 0.05),suggesting that the treatment schemes of the two groups can significantly improve TCM syndrome.After the medication cycle,the total quantitative scores of TCM syndromes in the treatment group and the control group were 2.00(1.00,3.50)and 5.50(3.00,11.50)respectively.There was significant difference between the two groups(P = 0.002 < 0.05),suggesting that the remission degree of TCM syndromes in the treatment group was greater than that in the control group.3.Main symptoms and secondary symptoms of traditional Chinese medicine: the scores of main symptoms and secondary symptoms in the treatment group after completing the medication cycle decreased to varying degrees compared with those before medication(P < 0.05);In the control group,except that the symptoms of anal burning were not improved(P = 0.132 > 0.05),the scores of other main and secondary symptoms after taking the medicine were lower than those before taking the medicine(P< 0.05).After completing the medication cycle,there was no difference between the two groups(P > 0.05);There were significant differences in diarrhea,mucus purulent and bloody stool,abdominal pain,fatigue and fatigue,anal burning,abdominal distension,dry mouth and bitter mouth(P < 0.05),suggesting that the relief degree of diarrhea,mucus purulent and bloody stool,abdominal pain,fatigue and fatigue,anal burning,abdominal distension,dry mouth and bitter mouth in the treatment group was greater than that in the control group,but there was no difference in the curative effect of internal urgency and heavy weight,short and red urine.4.Total curative effect: after completing the medication cycle,26 cases in the treatment group were effective and 4 cases were ineffective,with a total effective rate of 86.67%;In the control group,21 cases were effective and 9 cases were ineffective.The total effective rate was70.00%;The total effective rate of the treatment group was higher,P =0.032 < 0.05,suggesting that the treatment effect of Western medicine combined with Shaoyao decoction is better than that of Western medicine alone.5.Morphology of mucosal lesions under colonoscopy: the endoscopic score of the two groups was lower than that before medication(P = 0.000< 0.05).The endoscopic score of the treatment group was 0.00(0.00,1.00)and that of the control group was 1.00(0.00,2.00).The score data of the two groups were compared,P = 0.018 < 0.05,suggesting that the treatment schemes of the two groups can improve the morphology of intestinal mucosal lesions,and the improvement effect of the treatment group is greater than that of the control group.6.Ibdq scale score: the ibdq scale score of the two groups was higher after administration than before administration(P = 0.000 < 0.05).The score of the treatment group was 176.53 ± 16.062 and that of the control group was 168.27 ± 11.368.Compared with the score data of the two groups,P = 0.025 < 0.05,suggesting that the treatment schemes of the two groups can improve the quality of life of patients to varying degrees,and the improvement degree of the treatment group is greater than that of the control group.7.During the medication period,the vital signs of the two groups were generally stable,and no safety related events such as adverse reactions were reported.Conclusion: The application of Shaoyao decoction combined with western medicine mesalazine can significantly improve the clinical symptoms and intestinal mucosal state of patients with damp heat accumulation ulcerative colitis,improve the quality of life,achieve ideal results,have less adverse reactions and good safety,and can be popularized and used in clinic. |
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