Efficacy And Safety Of 308nm Excimer Light In Home And Hospital Treatment Of Vitiligo

Objective: To compare the efficacy and safety of home 308 nm excimer light and hospital 308 nm excimer light in the treatment of vitiligo patients;to provide reference for the revision of vitiligo family phototherapy guidelines and consensus,and the design of clinical pathways.Methods: A single-center,prospective study of 58 patients with vitiligo who underwent home phototherapy and hospital phototherapy was selected and divided into a home phototherapy group and a hospital phototherapy group.The two groups of phototherapy regimens were the same,3 times a week for 3 months.The plaque pigmentation,quality of life scores,and related complications and adverse events were collected and recorded before and 3 months after phototherapy.Results: 1.There was no significant difference in gender,age,skin type,course of vitiligo,plaque quantity,quality of life score and previous vitiligo treatment method between the home phototherapy group and the hospital phototherapy group.2.There was no significant difference in the effective and marked repigmentation rates of target plaques between the home phototherapy group and the hospital phototherapy group after 3 months of 308 nm excimer phototherapy.3.There was no significant difference in the effective and markedly effective rates of plaque pigmentation on the head and neck,hands and feet,and other parts of the patients in the home phototherapy group and the hospital phototherapy group after 3 months of 308 nm excimer phototherapy.4.There was no significant difference in the effective rate of plaque pigmentation after 3 months of 308 nm excimer phototherapy in the short-term group(≤24 months)and the long-term group(>24 months);while the difference in the marked rate was statistically significant.5.The incidence of complications in the home phototherapy group and the hospital phototherapy group were 17.2% and 11.5%,respectively,and the difference was not statistically significant.6.Compared with before phototherapy,the quality of life scores of patients in the home phototherapy group and hospital phototherapy group after 3 months of 308 nm excimer phototherapy were significantly lower,and the difference was statistically significant.Conclusion: 1.Both home 308 nm excimer light and hospital 308 nm excimer light can significantly improve the clinical symptoms of patients,improve the quality of life of patients.2.The efficacy of 308 nm excimer light at home and 308 nm excimer light in hospital in the treatment of vitiligo is similar,and there is no significant difference in the incidence of complications and safety between the two.3.Compared with the 308 nm excimer light in the hospital,the 308 nm excimer light in the home has the advantages of convenient portability,simple operation and high patient compliance,which is worthy of clinical application.