Study On The Clinical Efficacy Of Jiangya Anshen Decoction On Hypertensive Patients With Insomnia And Its Influence On Blood Pressure Variability

Objective:To observe the clinical efficacy of Jiangya Anshen Drink on patients with hypertension and insomnia(yin deficiency and yang hyperactivity type),evaluate and analyze the effectiveness of Jiangya Anshen Drink on patients with resting blood pressure,24h short-term ambulatory blood pressure,TCM syndromes and sleep quality,and provide more clinical data for patients with hypertension and insomnia(yin deficiency and yang hyperactivity type)to stabilize blood pressure fluctuations and improve sleep quality.Methods:From December 2021 to December 2022,a total of 80 outpatients and inpatients with primary hypertension of grade 1 and grade 2 combined with insomnia diagnosed by the Department of Hypertension of Jinan Hospital of Traditional Chinese Medicine were randomly divided into treatment group(TG)and control group(CG)with 40 cases each.The CG was treated with amlodipine besylate tablets and alprazolam,and the TG was treated with amlodipine besylate tablets and alprazolam combined with selfdesigned hypotensive Anshen drink,After 4 weeks,the patients’ resting blood pressure,24hour short-term ambulatory blood pressure and coefficient of variation,the score of TCM syndromes and the Pittsburgh sleep quality index were observed.Results:1.In terms of resting blood pressure:SBP and DBP in the two groups decreased after treatment,and the effect of reducing SBP and DBP in the TG was better than that in the CG(P<0.05).2.In terms of 24h short-term ambulatory blood pressure and coefficient of variation:24h ambulatory blood pressure levels in both groups showed a downward trend after treatment.Patients in the TG were better than those in the CG in controlling 24h MSBP,24h MDBP,DMSBP,DMDBP,NMSBPs NMDBP(P<0.05).The coefficient of variation of ambulatory blood pressure at 24 hours after treatment in both groups was lower than that before,and the dipper blood pressure pattern was higher than that before,among which the patients in the TG were better than those in the CG in improving 24 hours MSBPCV,DMSBPCV and blood pressure pattern(P<0.05).3.In terms of TCM syndrome score:All TCM syndromes in the two groups were improved after treatment,and the TG was better than the CG in relieving symptoms of dizziness,headache,insomnia,palpitation,five-heart fever and tinnitus(P<0.05).4.Pittsburgh sleep index:The PSQI score of the two groups after treatment was lower than that before,and the sleep quality of patients in the TG was better than that in the CG(P<0.05).Conclusion:1.Jiangya Anshen Decoction has a significant effect on blood pressure regulation in patients with hypertension and insomnia(yin deficiency and yang hyperactivity type),and it can significantly improve resting blood pressure,24-hour ambulatory blood pressure,blood pressure variation coefficient and blood pressure circadian rhythm.2.Jiangya Anshen Decoction can significantly improve many TCM syndromes of patients with hypertension and insomnia(yin deficiency and yang hyperactivity).3.Jiangya Anshen Drink can improve the sleep status of patients with hypertension and insomnia(yin deficiency and yang hyperactivity).