Study On The Etiology And Pathogenesis And Drug Rule Of COVID-19 Based On Data Mining

1.Purpose of the studyThis thesis analyzes the different clinical manifestations of mild,common,severe and critical COVID-19 and their variants in seven regions in China,studies the etiology,pathogenesis and the variation of COVID-19,and try to find out the medication rule applied for the treatment of COVID-19 in different regions of the country by analyzing the clinical diagnosis and treatment literature of traditional Chinese medicine in the past three years(2020-2022).2.Research methodsHaving searched all the literature on the treatment of COVID-19 by traditional Chinese medicine,from China National Knowledge Network(CNKI),Wanfang Data Knowledge service platform(Wanfang Data)and Chinese Science and technology journal database(VIP)from January 1,2020 to May 30,2022,of which the literature related to the COVID-19 variant was screened out up to July30,2022,all the basic information of the patient,the city,the province to which he is located,clinical symptoms,and tongue image,pulse,clinical classification,prescription,traditional Chinese medicine and other original data are entered into the Excel table,a database is established,and data standardization is processed.Combined with literature research method and data mining method,SPSS Modeler 18.0 and SPSS 23.0 were used to carry out frequency statistics,chi-square test,association rule analysis,cluster analysis,etc.According to the seven geographical divisions of China,and summarize the clinical manifestations,etiological characteristics,pathogenesis evolution and medication rules of different regions and types of COVID-19.3.Research results94 articles were included,involving a total of 11,766 patients,including 12 clinical diagnosis and treatment literature with different clinical classifications,12 literature on the diagnosis and treatment of new coronavirus variants,and 27 literature on traditional Chinese medicine formulas and traditional Chinese medicine information.(1)Clinical manifestations in different regionsThrough the zonal statistics of the clinical manifestations of COVID-19 in the seven major regions,the common clinical manifestations of COVID-19 in each district are fever,fatigue,cough,and sputum,the coated tongue also looks quite different,the pulse feel different too.In addition,there are also some clinical differences in each district,and the symptoms in each district are compared with those in central China,and the specific differences are:The sore throat in North China is obvious,while the symptoms such as cough,sputum,fatigue,sweating,pant are mild,the coating on the tongue will be described in Chinese as "baitai",huangtai and nitai(thick coating on the tongue);Pulse condition is called "huamai," "rumai"and "xuanmai"in Chinese.In the northeast region,poor feeding,nausea,abdominal distention symptoms,cough,sputum and other pulmonary symptoms,chills,nasal congestion symptoms are obvious,chest tightness,fatigue,dry cough is rare,the coating on the tongue is pale,white,dark,thick,tooth mark,etc.,pulse conditions are "huamai" and "rumai" in Chinese.In the northwest region,fatigue and shortness of breath are obvious,red tongue and dark red tongue are more common in tongue texture,the coating on the tougue is thick,the pulse condition is "rumai" in Chinese.The symptom of mouth parched and tongue scorched is obvious in southwest China,the coating on the tongue is white and thin.The pulse condition is "shumai","huamai","ximai" in Chinese.In South China,head symptoms such as dry cough,dizziness and headache are obvious,the coating on the tongue are white.The pulse condition include "shumai","huamai",In East China,the symptoms such as fever,sweating,thirst are obvious,the coating on the tongue are white,yellow,thin and thick.The pulse conditions include"shumai" "huamai" and "rumai".(2)Clinical manifestations of different typesThe mild symptoms are low-grade fever or no fever,fatigue,cough,dry cough,the coating on the tongue is thin and white,the pulse condition is called "rumai" or"huamai" in Chinese.The common symptoms of the patients include low-grade or medium-high fever,fatigue,cough,sputum production,chest tightness,sleeplessness,sore throat,dry throat,nausea,vomiting,fat tongue,light red or red tongue,the coating of the togue is white or yellow,the pulse conditions are called "huamai" or"xuanmai".Severe symptoms of the patients can be seen as fever,polydipsia,cough,sputum,blood in sputum,nausea,vomiting,dizziness,shortness of breath,or macules,or vomiting blood,sweating,cold limbs,fatigue,red tongue or thick coated tongue.the pulse conditions are called "huamai "or "shumai" "ximai","chenmai" in Chinese.The clinical manifestations of mild,common and severe disease show the development process of the disease from mild to severe.Compared with the common type,mild type is more manifested as low-grade fever,dry cough and sputum production,etc..The tongue nature is teeth-printed,the coating on tongue is white and thin,while the chest tightness,sleeplessness and other cardiac symptoms,poor feeding,nausea,vomiting,spleen and stomach symptoms,sore throat,dry throat and other abnormal fluid metabolism and other symptoms are less.Compared with the common type,the symptoms of severe patients are moderate heat,high fever,fatigue,sweating and shortness of breath,the tongue nature is teeth-printed or fissured,the coating on the tongue is moist or dry.The pulse manifestation is called "huamai","shumai","ximai","chenmai",are more common.In addition,the severe symptoms of patients severe include fever,polydipsia,dizziness,blood in sputum,or macules,or vomiting blood,limb convulsions,sweating,cold limbs and other symptoms.(3)Clinical manifestations of new coronavirus variants in different regionsThe clinical manifestations of the new coronavirus variant can include fever,fatigue,muscle aches,sore throat,chest tightness,nasal congestion,sluggishness,nausea,etc.,red or light red tongue,white or thin white coated tongue,pulse feels slippery,fine or tight.Compared with North China,pulmonary symptoms such as cough and sputum production are more common in Northeast China,spleen and stomach symptoms such as poor feeding and abnormal stool,and abnormal symptoms of fluid metabolism such as thirst and bitter mouth.In South China,fatigue,fever,and poor appetite are more common,and the tongue nature is more pale,thin and tender,and the coating on tongue is white;In East China,symptoms such as nasal congestion and nasal discharge are more common,the pulse feels floating.(4)Medication rules in different regionsThe treatment of COVID-19 is mainly used in combination with spicy,bitter or spicy,bitter and sweet,mainly attributed to lung meridian,spleen meridian and stomach meridian,among which high-frequency drugs mainly include "buxu"medicine,"huashi" medicine,and e for phlegm,cough and asthma,and antipyretic medicine.Specific drugs are Codonopsis,Panax ginseng,Poria,Coix Kernel,Patchouli,Cangzhu,Bitter Almond,Forsythia,Honeysuckle,etc.Based on the results of the association analysis of high-frequency drugs in different regions,the common drug pairs include "Poria-Codonopsis","Coix Kernel-Codonopsis","Zhimu-Scutellaria baicalensis","Raw gypsum-bitter almond","Poria-Baishu" and "Poria-tangerine peel","Banxia-Magnolia","Magnolia-cardamom",etc.;The strong correlation between the three flavor medicines is "winter melon seed-peach kernel-reed root","kudzu-jujube-ginger" and"skullcap-Chaihu-Banxia","Zhuo Ling-Tangerine Peel-Banxia",etc.Based on the results of high-frequency TCM clustering analysis in different regions,the commonly core prescriptions are:Yinqiao Shan in North China,Xiaoqinglong Tang and Dayuan Drink in Northeast China,Four Gentlemen’s Soup,Ma Xingshi Gan Soup,Four Junxi Soups in Southwest China,Xiaochengqi Soups in South China,Maxing Shi Gan Soup,Fuling Gancao Soup,Xiaochai Hu Tang,Banxia Houpu Soup,and Fuling Gancao Soups in East China.4.Research conclusions(1)Clinical manifestationsThe clinical manifestations of COVID-19 in different regions are slightly different,and there are dry images in different regions,such as dry cough and dry mouth;and signs of wind and heat,such as fever,thirst,sweating,coating on the tongue is yellow and greasy;It is also the difference between wind and cold signs,such as nasal congestion,sneezing,pale tongue or white,and white coating on the tongue.It is related to the regional differences,climatic differences and disease seasons between the seven major sub-regions.(2)Etiology and pathogenesisThe basic pathogenesis of COVID-19 is that the wet epidemic virus is lurking in the membrane.The disease is routed in the membrane,which is related to the lungs,spleen,stomach,and brain.The type of disease is latent and post-onset,and the etiological attribute is wet epidemic toxin.The wet epidemic toxin has the characteristics of first invading the lung,injuring the spleen and stomach,easily blinding the orifices,easily transforming heat and injuring the body fluid,and easily damaging the yang qi.Insufficient qi is the fundamental cause of the onset of COVID-19,and qi deficiency runs through the entire process of COVID-19.(3)Pathogenesis evolutionThe onset of COVID-19 is that wet epidemic virus enters from the mouth and nose,lurking in the upper membrane.Light wet epidemic virus stops polymerizing,Yang qi is inhibited,and can go out from the original membrane to the surface,manifested as the same disease in the surface.The common type of wet epidemic virus spreads inward from the membrane,affecting the lungs and spleen,with moisture resistance focus as the core pathogenesis.Severe wet epidemic virus fever,epidemic virus closed lungs,heat into the camp blood,blood consumption,or manifested as qi camp burnt.If it is prolonged or mistreated,the danger of internal closure and external removal can be seen.During the recovery period,the disease mechanism is a deficiency of qi vanishing,and the remaining evil is not exhausted.(4)Medication rulesThe drug to treat COVID-19 is mainly spicy and bitter,and it mainly includes"buxu"medicine,"huashi" medicine,and medicine for the cure of phlegm,cough,asthma,diuretic,and antipyretic medicine.Common drugs in treatment COVID-19 are combination of "buyi" medicine and"lishuishenshi" medicine;"qingre" medicine and "huoxuehuayu" medicine;"liqi"medicine and "jianpilishi" medicine and etc.For examples:"Yiyiren-ginseng","benincasa seed-peach kernel-reed root" and "poria"-Tangerine peel "Houpu wenzhong soup".Commonly used treatment formulas have the effect of"Buyizhongzhou",or promoting qi and water,dispelling dampness,or"Shuzhuanshaoyang",and "Kaidamoyuan",such as Decoction of Four Mild Drugs,Xiaoqinglong Soup,Poria Cocos Licorice Soup,Banxia Magnolia Soup,Xiaochaihu Soup,Dayuan Drink.In the treatment of COVID-19,attention is paid to the"penetration" method,which is intended to promote the qichang,solve the surface clearing,and penetrate the membrane.