Study On The Correlation Between Atherogenic Index Of Plasma And Asthma In Children

ObjectiveTo investigate the relationship between atherogenic index of plasma(AIP)and childhood asthma,to provide data for domestic research on blood lipids and asthma.MethodsAsthma was diagnosed according to the Global Initiative for Asthma(GINA).86 asthmatic children aged 2~13 years old who were hospitalized in the pediatric department of Changzhou Second People’s Hospital from July 2020 to August 2022 were collected as asthma group,and 149 healthy children aged 2~13 years old who underwent physical examination in Changzhou Second People’s Hospital at the same time were selected as control group.Collected and recorded the children’s sex,age,history of specific dermatitis,history of inhaled allergen allergy,family history of asthma(which is whether parents have or have had asthma)and feeding history(including breastfeeding,mixed feeding,artificial feeding),conducted health examination and blood sampling under fasting condition,children’s weight,height,total cholesterol(TC),triglyceride(TG),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C),blood glucose were recorded,AIP and body mass index(BMI)were calculated.The correlation among AIP,independent blood lipids(TG,HDL-C)and asthma and the comparison of diagnostic value of asthma were studied by multivariate logistic regression analysis and receiver operating characteristic curve(ROC curve).Results1.Comparison between asthma group and control group:age,sex ratio and BMI between asthma group and control group have no significant difference(P>0.05).The height and weight of control group were lower than those of asthma group(P<0.05).The proportion of children with inhaled allergen allergy,history of specific dermatitis and family history of asthma in asthma group were higher than those in control group(P<0.05);As for feeding history,the proportion of mixed feeding in asthma group was higher than that in control group,while the proportion of artificial feeding in the control group was more(P<0.05),while the difference between two groups in breastfeeding was not statistically significant(P>0.05).2.Analysis of metabolism-related indicators in asthma group and control group: the blood glucose,TG and AIP in control group were lower than those in asthma group,while HDL-C was higher than that in asthma group(P<0.05);TC and LDL-C between the two groups had no significant different(P>0.05);according to the age stages,the participating children were divided into three group including toddler,preschool and school-age periods.Among them,the asthma group of toddler period had higher levels of TG and AIP,and the difference was statistically significant(P<0.05),while there was no significant difference in blood glucose,TC,HDL-C and LDL-C between the two groups(P>0.05).The asthma group of preschool children had higher levels of blood glucose,TC,LDL-C and AIP,while the HDL-C in asthma group was lower,the difference among them was statistically significant(P<0.05);and there was no statistically significant difference in TG between the two groups(P>0.05).The asthma group of school-age children had higher blood glucose and AIP levels,and the difference was statistically significant(P<0.05),but there was no statistically significant difference in TC,TG,HDL-C,LDL-C between the two groups(P>0.05).3.Related risk factors affecting asthma were analyzed: in model 1 without adjusting of possible confounding factors,TG and AIP were positively correlated with asthma[TG: OR=2.336(95%CI 1.264~4.316),P=0.007;AIP: OR=13.356(95%CI 4.158~42.904),P<0.001],while HDL-C was negatively correlated with asthma [HDL-C: OR=0.141(95%CI 0.056~0.360),P<0.001];After adjusting height,weight and blood glucose in model 2,TG and AIP were positively correlated with asthma,while HDL-C was negatively correlated with asthma[TG: OR=2.206(95%CI 1.046~4.654),P=0.038;AIP:OR=20.232(95%CI 4.761~85.980),P<0.001;HDL-C: OR=0.065(95%CI 0.019~0.220),P<0.001].After adjusting the possible confounding factors,like height,weight,whether there was specific dermatitis,whether there was a history of inhaled allergen allergy,whether there was a family history of asthma,feeding history,blood glucose in model 3,TG,AIP,HDL-C were still correlated with asthma [TG: OR=2.741(95%CI 1.011~7.437),P=0.048;AIP: OR=24.784(95%CI 2.541~241.762),P=0.006;HDL-C: OR=0.021(95%CI 0.002~0.234),P=0.002].4.Compared the diagnostic value of AIP and independent blood lipid indicators(including TG and HDL-C)in asthma: in the comparison of the diagnostic value of AIP,TG and HDL-C in predicting asthma,the diagnostic value of AIP was significantly higher than that of TG(P<0.05),but there was no statistically significant difference between AIP and HDL-C in diagnosis value(P>0.05).Conclusions1.Comparison of blood lipids and AIP between asthma group and control group: the levels of TG and AIP in asthma group were significantly higher,HDL-C was lower.The difference of blood lipids between the asthma group and the control group may change at different age stages,but the AIP level of the asthma group was always higher than that of the control group at different age stages,and the AIP may not be affected by the change of age stages.2.Correlation analysis among blood lipids,AIP and asthma: TG and AIP were positively correlated with asthma,while HDL-C was negatively correlated with asthma.3.In analysis and comparison of the diagnostic value of AIP and independent blood lipid indexes for asthma: AIP,HDL-C,TG had certain significance in the diagnosis of asthma;AIP had higher diagnostic value for asthma than TG,and it was a biomarker with better diagnostic value for asthma.