Correlation Between Plasma Atherogenic Index And The Degree Of Coronary Artery Disease In Postmenopausal Women

Objective: The purpose of this study was to investigate the association between plasma atherogenic index(AIP)and the risk of postmenopausal coronary heart disease and the severity of coronary artery disease in women,and to find out whether plasma atherogenic index(AIP)might be a better indicator to predict the risk of coronary heart disease in postmenopausal women.Methods: In this study,443 postmenopausal women who were admitted to the cardiology department of Tianjin first central hospital for coronary heart disease due to chest pain and other symptoms and underwent coronary angiography and percutaneous coronary stent implantation when necessary were selected and divided into the coronary heart disease group(308 cases)and the control group(135 cases)according to the results of coronary angiography.In addition,patients in the coronary heart disease group were graded according to the Gensini score according to the results of coronary angiography and the degree of coronary artery lesions and stenosis,and then the patients in the coronary heart disease group were divided into three subgroups according to the scoring results,namely,the Gensini score <40 group,the Gensini score <80 group,and the Gensini score 80 group.Collect all included in the study of the patient’s general information and laboratory tests,including age,smoking history of high blood pressure and diabetes status of clinical and demographic characteristics of the data,the experimental data,including urea nitrogen,creatinine,uric acid fasting glucose bilirubin lipid parameters such as total cholesterol(TC),low density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C),triglyceride(TG)and very low density lipoprotein cholesterol(VLDL),etc.Plasma atherogenic index(AIP),non-hdl-c atherosclerosis index(AI)and lipoprotein association index(LCI)were calculated.Results: There were statistically significant differences between the postmenopause women CHD group and the control group in hypertension,diabetes,smoking,age,systolic blood pressure,fasting blood glucose and traditional blood lipid indexes for exa TG,TC,LDL-C and HDL-C(P<0.05).And the HDL-C value of CHD group was significantly lower than that of control group,and the LDL-C value was significantly higher than that of control group.Non-HDL-C,AI,and LCI had statistical significance in CHD group and control group(P < 0.05).There were statistically significant differences in hypertension,diabetes,smoking,age,TG,TC,LDL-C,HDL-C,Non-HDL-C,AI,and LCI among the subgroups of CHD in postmenopausal women(P<0.05).There was no significant difference in systolic blood pressure and fasting blood glucose between the subgroups of CHD(P>0.05).AIP values of postmenopausal women in CHD group and control group were statistically different(P<0.01).AIP of CHD group was significantly higher than that of control group.There was significant correlation between AIP and Gesini scores,TG,TC,LDL-C,HDL-C,Non-HDL-C,AI,LCI and age in postmenopausal women with coronary heart disease.Conclusions:1.Plasma AIP and LDL-C were independent risk factors for postmenopausal women with coronary heart disease,while HDL-C was independent protective factor.2.There was a positive correlation between AIP and the Gensini score for coronary heart disease,and it could reflect the lipid metabolism level of postmenopausal women with coronary heart disease.3.AIP can predict the degree of coronary artery stenosis and indirectly assess the prognosis of postmenopausal women with coronary heart disease.