Based On Data Mining To Study The Pattern Of Evidence And Treatment Of Diabetic Nephropathy Stage Ⅲ And Ⅳ Proteinuria In Chinese Medicine

Objective:Based on data mining technology to investigate the clinical experience of Chinese medicine in treating stage III and IV proteinuria in diabetic nephropathy,describe the distribution of the evidence and the medication pattern,and provide some statistical support for the rational use of clinical medicine.Methods:1.Search the China Knowledge Network,Wanfang,and Vipshop clinical research literature for the treatment of diabetic nephropathy stage III and IV proteinuria from January 2003 to January 2023.2.Choose the inclusion and exclusion criteria for the study’s objective in mind when screening the literature.3.To create a database,the names of prescriptions,drug composition,and dosage from the selected literature were entered into an Excel sheet.4.The tools SPSS Modeler 18.0 and SPSS Statistics 26.0 examined the condensed data for association rules and clustering,obtain and analyze the results of HF herbs,core pairs,new prescriptions,and visualization in compounding.Results:1.Diabetic nephropathy stage III involves 307 prescriptions and 225 herbs.Diabetic nephropathy stage IV involves 156 prescriptions and 213 herbal medicines.The common high-frequency drug and dosage for both phases is Radix Astragali30 g,15g of yam,Radix Salviae Miltiorrhizae,poria cocos and Radix Rehmanniae,Cornus officinalis is commonly used in stage III at 10 g and in stage IV at 15 g.Rhubarb is commonly used in stage III at 6g and in stage IV at 10 g.Alismatis Rhizomais commonly used in stage III at 10 g and in stage IV at 10 g or 15 g.Different drugs:phase III:Gorgon fruit 15g;Phase IV : Atractylodes Macrocephalae 15 g.2.Statistical analysis of medicinal properties: In both phases,the frequency of the four qi of the drugs used are mainly warm,cold and flat,and the five flavours are mainly sweet.On the meridian tropism,the liver,kidney,and spleen meridians are the main channels in Phase III,while the liver,spleen,and kidney meridians are the main channels in Phase IV.3.Association Rule Analysis:By creating corresponding conditions for high-frequency drugs,19 groups of regular drug use pairs were found in phase III and 18 groups of regular drug use pairs in phase IV.Yam-Astragalus and Salvia-Astragalus are two identical HF drug pairs in two phases.4.Cluster analysis: New formula combinations for stage III diabetic nephropathy revolve around Shenqi Dihuang Decoction,Shuilu Erxian Pill and Liuwei Dihuang Pill;stage IV revolve around Shui Lu Er Xian Dan,Ji Dang Tang and Ren Qi Wan.5.Statistical Analysis of TCM Syndrome Types: In stage III of diabetic nephropathy,Qi and Yin deficiency evidence predominates,while blood stasis evidence makes up the majority of symptoms.In stage IV,spleen and renal deficiency evidence predominates,while turbidity and toxicity evidence make up the majority of symptoms.6.Medication patterns of common TCM syndromes in different stages:The core drug combination of qi yin deficiency syndrome is astragalus,salvia miltiorrhiza,cornus officinalis,rehmannia glutinosa,yam,poria cocos,rhubarb,rhizoma alismatis,ophiopogon japonicus,and rhizoma chuanxiong;The core drug combinations for blood stasis syndrome include Astragalus,Poria cocos,Salvia miltiorrhiza,Alisma orientalis,Euryale,Angelica,Chuanxiong,Atractylodes macrocephala,Leech,and Rhubarb;The core drug combinations for spleen and kidney deficiency syndrome include astragalus,salvia miltiorrhiza,poria cocos,yams,rhubarb,atractylodes macrocephala,angelica,cornus officinalis,chuanxiong,and thicket fruit;The core drug combination for turbid toxin syndrome is Huangqi,Tuporia cocos,Danshen,rhubarb,Poria cocos,Angelica sinensis,Cornus officinalis,Atractylodes macrocephala,Rehmannia glutinosa,and White Bombyx mori.Conclusion:1.The common core herbs for diabetic nephropathy stages III and IV are astragalus,Chinese yam,salvia miltiorrhiza,poria cocos,raw rehmannia,cornus officinalis,alisma orientalis,rhubarb and angelica sinensis.Different drugs: Phase III is Gorgonzola,and Phase IV is Atractylodes macrocephala.The medicinal properties are mainly sweet and warm,mostly to the liver,spleen and kidney meridians.2.In stage III of diabetic nephropathy,Qi and Yin deficiency evidence predominates,while blood stasis evidence makes up the majority of symptoms.In stage IV,spleen and renal deficiency evidence predominates,while turbidity and toxicity evidence make up the majority of symptoms.3.The overall core drug pair and new formula combination for diabetes nephropathy phase III are mainly Shenqi Dihuang Decoction,Shuilu Erxian Pill,Liuwei Dihuang Pill,with the combination of Sheng Wei San in Qi and Yin deficiency evidence,and the combination of Tao Ren and Hong Hua in blood stasis evidence.Treatment is based on tonifying Qi,nourishing Yin,clearing heat,tonifying the spleen,consolidating the kidney and regulating essence.4.The overall core drug pairs and new formula combinations in stage IV are based on Daidang Tang and kidney Qi Pill,and the same drugs are used for both spleen and kidney deficiency,while the drug combinations of Cicada Mucuna Pruriens and Sclerotinia Sinensis are seen in the turbid toxicity evidence.Treatment is based on supporting the vital energy,activating blood circulation,removing blood stasis,detoxifying and clearing the ligaments.