The Rsearch On Medication Rule Of Chronic Cough In Adults That Is Based On Data Mining Technology

Objective: A retrospective study was conducted using data mining techniques to investigate the patterns of Chinese medicine use in modern literature for the treatment of chronic cough,with a view to better summarizing the clinical use characteristics and providing reference for the clinical treatment of chronic cough.Methods: Randomized controlled trials(RCTs)related to TCM for chronic cough were collected from January 2012 to December 2022 published in China Knowledge Network(CNKI),Vip Info(VIP)and Wanfang Data.Using Excel 2019,SPSS Modeler18.0,SPSS Statistics 26 and Cytoscape,the frequencies,tastes,and ascriptions of the drugs involved were organized into a database,and frequency statistics,association rules,systematic clustering and complex network presentation were used to summarize and analyze the data.Results:1.This study initially collected more than 400 papers,including 285 papers that meet the criteria for nadir,285 prescriptions were collected,with a total number of 3102 drugs,involving 236 Chinese herbs,with a high frequency of recipes such as stopping cough,Ling Gan Wu Wei Jiang Xin Tang,Er Chen Tang,etc.,with a high frequency of efficacy in terms of dispelling wind and cough,and also includes a part of self-prepared recipes.2.The top ten Chinese herbal medicines in terms of frequency are: licorice,orris,bitter almond,aster,chenpi,fenugreek,bupleurum,poria,roasted licorice,cicada,etc.,which are mostly classified as lung,spleen,stomach,heart and liver.Drugs to resolve phlegm to relieve cough and asthma most,followed by tonic for deficiency,relieving the symptoms,and clearing heat.3.The four qi classification of drugs are mostly warm drugs,followed by flat,slightly warm,cold,slightly cold,etc.Among the five flavors,sweet drugs account for the largest proportion,followed by bitter,pungent,slightly bitter,sour,etc.4.According to the analysis of association rules to get to the confidence of the top five drug combinations are armeniaca amara→ephedra,licorice → ephedra,platycodon grandiflorum → cynanchum glaucescens,platycodon grandiflorum →schizonepeta,armeniaca amara→ loquat leaf,according to the cluster analysis to get eight groups of drug combinations,and the core prescription is: platycodon grandiflora,aster tataricu,licorice,dried tangerine,pinellia tuber,poria,saposhnikoviae radix,cicada slough,fritillaria thunbergii,armeniaca amara,scutellaria.Conclusion: After collecting and statistically analyzing the data of the herbal medicines involved in the included literature,it was found that the variety of drugs involved is rich,and the overall is in line with the idea of disease identification and identification.The etiology is mainly wind and phlegm,and wind evil can be mixed with cold,damp,heat and dryness,etc.The factor of internal injury cannot be ignored,and can involve the lung,spleen,stomach,heart and liver,and the combination of internal and external evil.The pathogenesis of the disease is based on wind attacking the lung and coughing when the lung qi goes up.Treatment is based on wind and phlegm,with the main focus on resolving phlegm and relieving cough to dispel wind,and taking into account the regulation of the internal organs to support and dispel evil.In the collected prescriptions,the prescriptions of sutra and prescriptions of the time are used,and the selection of drugs emphasizes cold and warmth and is used to harmonize the organism,with the taste of medicine being mostly warm,sweet and bitter,and the combination of pungency and bitterness to regulate the lung qi.In terms of drug efficacy,most of the drugs are used to resolve phlegm,stop coughing and calm asthma,followed by deficiency tonic drugs,relieving symptoms and clearing heat;the combination of drugs is combined with disease identification and evidence,and more wind drugs are used to dispel wind evil,and good pairs of drugs are used.The literature included in this study shows that TCM is effective in treating chronic cough,providing some clinical theoretical support for further excavation and development of TCM for chronic cough,and attempting to further enhance clinical efficacy by excavating new prescriptions.