Chronic Cough Syndrome Distribution And Medication Analysis Of Chronic Cough Of Liver-fire Attacking Lung Type Based On Data Minin

Purpose:By using the method of data mining,the distribution of syndromes and elements in patients with chronic cough and medication characteristics of ganhuofanfei type chronic cough were analyzed and summarized,so as to provide reference for clinical treatment.Materials and Methods:1.Based on literature analysis,the distribution of syndrome elements in patients with chronic cough was studied,and Note Express V3.0 software was used to electronically search the literature included in CNKI,VIP and Wanfang databases.’Cough variant asthma or cough variant asthma and traditional Chinese medicine ’,’ upper airway cough syndrome or postnasal drip syndrome or postnasal drip syndrome and traditional Chinese medicine ’,’ gastroesophageal reflux cough and traditional Chinese medicine ’,’ eosinophilic bronchitis and traditional Chinese medicine ’,’ allergic cough and traditional Chinese medicine ’,’ chronic cough and traditional Chinese medicine ’ were used as keywords or titles and the time was limited from 2012 to 2022.According to the inclusion and exclusion criteria,the retrieved literatures were input into Excel to establish a database of syndromes and syndromes.Import it into SPSS software for analysis and get the results.2.In this study,the information of patients with chronic cough of ganhuofanfei type who were admitted to the respiratory department of the affiliated hospital of Liaoning university of traditional Chinese medicine from September 2021 to June 2022 and met the inclusion criteria was collected.According to the inclusion and exclusion criteria,accurate and complete medical records were selected and recorded.The data of medical records were analyzed by SPSS software to obtain the frequency of general information,drugs and prescriptions,and the results were analyzed.Then,statistical software was used for complex network analysis and cluster analysis of high-frequency drugs to obtain core prescriptions.Results:1.Based on the literature of chronic cough with clear syndrome types,335 qualified literatures were finally selected.After reading the literature content,85 different syndrome differentiation types were finally formed and included in the database for statistical analysis. A total of 26923 cases were collected.The top ten syndrome types accounted for the number of cases were fengxiefufei,fengtanzufei,fenghanxifei,tanshiyunfei,feiyinkuixu,ganhuofanfei,tanreyongfei,feipiqixu,qiyinliangxu,fengzaoshangfei.In addition to the fei,the syndrome elements of disease location ranked according to the number of cases were gan,pi,shen,wei,biao,bi,dachang,dan,wei and xin.The top ten syndrome elements of disease nature accounted for the number of cases were waifeng,tan,re,qi deficiency,yin deficiency,han,shi,zao,qizhi and yin.2.A total of 104 patients with chronic cough were included in this study,including 41 males and 63 females.There were 21 patients aged 18-30,22 patients aged 31-40,and 22 patients aged 41-51.A total of 129 traditional Chinese medicines were involved in 104 prescriptions.The top ten drugs used in frequency were bupleurum root,radix paeoniae alba,scutellaria baicalensis,bitter almond,poria cocos,perilla seed,rehmannia glutinosa,radix scrophulariae,cortex moutan,baiqian.;in the analysis of the four gases,han(59.54 %),wen(40.37 %)and ping(23.99 %)were the main;in the distribution of five flavors,ku(74.14 %),gan(52.86 %)and xin(50.84 %)were the main;in addition to licorice,five groups of core drug pairs were obtained by drug association analysis,namely bupleurum and radix paeoniae alba,scutellaria and bupleurum,bitter almond and bupleurum,rehmannia and radix scrophulariae,rehmannia and radix paeoniae alba.Four groups of core prescriptions were obtained by cluster analysis.The first group : almond,gypsum,rehmannia,radix scrophulariae,baiqian,loquat leaf,perilla seed,radix stemonae,cortex moutan,folium isatidis.The second group : tangerine peel,Fructus aurantii,Radix Scutellariae,Fructus Toosendan,Radix Bupleuri,Radix Paeoniae Alba.The third group : Pinellia,Magnolia,Licorice,Platycodon grandiflorum.The fourth group : Ophiopogon japonicus,Zhejiang fritillaria,Poria.Conclusion:1.According to the distribution of syndrome elements and syndrome types,it can be seen that fengxiefufei syndrome is the most common in chronic cough,accounting for 17.57 % of the total number of cases,with a frequency of 20.60 %.The most common internal injury cough was tanshiyunfei,accounting for 6.20 % of the total cases,and the frequency of occurrence was 10.45 %.Asthenia syndrome is more common in feiyinkuixu and feipiqixu,accounting for 4.94 % and 3.42 % respectively,and the frequency of occurrence is 8.66 % and 5.67 %.In terms of syndrome elements,waifeng is still the main factor leading to chronic cough,accounting for 44.79 % of the total number of cases,with a frequency of 56.12 %,followed by tan and re.The former accounts for 24.62 %,with a frequency of 34.63 %,and the latter accounts for 19.62 %,with a frequency of 29.26 %.In terms of Asthenia syndrome,qi deficiency and yin deficiency were the main ones,accounting for 15.52 % and 12.33 %respectively,with the frequency of 23.88 % and 18.51 %.In terms of disease location,except for the lung,the gan and pi were common disease locations,accounting for 7.23 % and6.28 %,and the frequency was 13.73 % and 9.25 %.2.According to the general situation and medication analysis of 104 patients,the distribution of chronic cough patients with ganhuofanfei type is mainly young and middle-aged women.It is speculated that it may be related to the vigorous qi and blood of young and middle-aged women and women ’s susceptibility to cough.In addition to fei and gan,the disease location mainly involves pi.However,due to the small sample size,further research is needed.Bupleuri Radix and Radix Paeoniae Alba,Radix Bupleuri Radix and Radix Scutellariae still occupy an important position in the treatment of chronic cough of liver fire invading lung type.Four groups of core prescriptions,the first group : almond,gypsum,Rehmanniae Radix,Scrophulariae Radix,Baiqian,Loquat Leaf,Perillae Fructus,Stemona,Cortex Moutan,Folium Isatidis.The second group : tangerine peel,Fructus aurantii,Radix Scutellariae,Fructus Toosendan,Radix Bupleuri,Radix Paeoniae Alba.The third group : Pinellia,Magnolia,Licorice,Platycodon grandiflorum.The fourth group : Ophiopogon japonicus,Zhejiang fritillaria,Poria,can be used as a circumstantial evidence to provide reference for clinical treatment.