Ancient Literature Research On Treatment Of Chronic Cough And Medication Rule Of Chronic Cough Treatment By Zhu Zhengang Based On Data Mining

Objective: To review the understanding of TCM ancient books on the name,etiology and pathogenesis of chronic cough and the treatment methods.To summarize Zhu Zhengang’s prescription and medication rule in the treatment of chronic cough.To explore the similarities and differences of clinical diagnosis and treatment of chronic cough between ancient and modern doctors.Based on the previous experience,we can expand the diagnosis and treatment of chronic cough to further guide the clinical treatment.Methods: Search the key terms "ke" and "sou" in the "Chinese Medical Classics".Screen out the elders who can reflect the course of cough.The searched ancient Chinese literature related to chronic cough was classified and summarized in terms of TCM disease names,etiology and pathogenesis,treatment methods and prescriptions,and preventive care.Data mining is carried out on the prescriptions for chronic cough in ancient books and Zhu Zhengang’s prescriptions for chronic cough by using "ancient and modern medical case cloud platform V2.2.1" software,focusing on the analysis of medication frequency,four natures of drugs,the five flavors and channel tropism.Through association analysis,prescription clustering and complex network analysis,Zhu Zhengang’s commonly used drugs,drug combinations and core combinations for chronic cough are summarized.Results: 1.Results of research on ancient books of chronic cough: The study on the name of chronic cough: There is no clear TCM disease name for chronic cough in ancient literature.Modern doctors generally think that chronic cough can be attributed to the categories of "Jiu ke","Jiu sou","entrails cough","wind cough","dry cough",and "virtuous cough".The study on the etiology and pathogenesis of chronic cough: Ancient Chinese medical practitioners believe that the causes of chronic cough in traditional Chinese medicine mainly include: stagnation of pathogenic factors such as wind,dampness,and dryness,emotional disorders,diet disorders,retention and medicine injuries,alcoholism,and overstrain.The study on the pathogenesis of chronic cough: Lung deficiency or mistreatment in the early stage of coughing leads to exogenous wind,dampness,dryness and other pathogenic factors stagnation in the lung;In the endogenous seven emotional frustrations,anger hurts the liver most often.Those who are irritable,when the Live-Fire is ascending,fire does metal,the cough often recurs;those who have improper diet such as food retention,alcohol,or those who have a weak spleen and stomach,Mizutani can’t lose to the lung,phlegm-dampness accumulated in the lung;chronic illness or asthenic overstrain results in viscera and frailty,which affects the lung and causes chronic cough.The study on the treatment methods of chronic cough:Most Ancient physicians believed that most of the chronic coughs were deficient and should be supplemented.The internal treatment methods are mainly tonic,warm,clear,attack,and eliminate.The main method is tonic,and pay attention to the deficiency of lung,spleen and kidney.External treatment methods include acupuncture,moxibustion,and smoking.The study on the prescriptions of chronic cough: 349 prescriptions were screened from the retrieved ancient literature,which contained 372 Chinese herbs.The highest frequency of medication is Poria(30.66%),followed by bitter almonds,Fritillaria chuanxiong,licorice,Schisandra,etc.;the channel tropism are lung,heart,and spleen;the four natures of drugs are mainly warm,flat,and slightly cold;the five flavors are mainly sweet,bitter and hard.The study on the preventive care of chronic cough: Pay attention to keep warm and avoid being exposed to wind and cold;Have a balanced diet,diet should be light and avoid salty food;Adjust work-leisure balance.Avoid excessive lust.2.Analysis of Zhu Zhengang’s medication rule in the treatment of chronic cough: in the 63 prescriptions of Zhu Zhengang in the treatment of chronic cough,100 Chinese herbs can be obtained.In addition to Liquorice,Ephedra(92.06%)was the most frequently used drug,followed by Stemonae,Aster,Cortex Magnoliae Officinalis,etc.The main drugs were relieving drugs and antitussive and expectorant drugs;The channel tropism are mainly lung,stomach and spleen;the five flavors are mainly pungent,bitter and sweet;the four natures of drugs are mainly warm drugs,followed by cold and flat drugs;Commonly used Chinese medicine pairs are Stemonae-Aster,White mustard-Schisandra chinensis,Saposhnikoviae Radix-Areca and Pinelliae Rhizoma-Fructus Amomi,etc.The core formula consists of Cough Relieving Powder.The Chinese medicine composition includes Ephedra,Stemonae,Aster,Cortex Magnoliae Officinalis,Cynanchum stauntonii,Armeniacae Semen Amarum,Angelica dahurica,Gardeniae Fructus Praeparatus,Arctii Fructus,Magnoliae Flos,Tangerine,White mustard,Mentha haplocalyx Briq,Chuanxiong Rhizoma and Liquorice.Conclusion: 1.Chronic cough belongs to the categories of "Jiu ke","Jiu sou","spleen cough","liver cough","heart cough","kidney cough","stomach cough","wind cough" and "dry cough".Ancient doctors believed that chronic cough belonged to the type of Deficiency in Origin and Excess in Superficiality.External evil attack on lung is the induction factor of disease.Weakness of viscera is the key reason for cough lingering.The treatment of chronic cough mainly uses temperature compensation method.While treating the lungs,it often takes care of the heart and spleen.2.Director Zhu Zhengang thinks that "wind" and "phlegm" are the key factors for chronic cough,and exogenous wind pathogen is the most common cause.The treatment of chronic cough is based on diffusing the lung and resolving phlegm,and pay attention to reinforce the spleen.3.Director Zhu Zhengang inherits the clinical thoughts of ancient doctors on chronic cough,and at the same time,combined with long-term clinical observation,forms his own point of view.Ancient doctors paid more attention to the chronic cough caused by the dysfunction of viscera,and the treatment was mainly tonic.Director Zhu Zhengang paid attention to the long cough caused by stagnation of exogenous wind and evil,and took "diffuse the lung and resolving phlegm" as the treatment core.