| Purpose:To explore the correlation between TCM Syndrome Types and apolipoprotein A and apolipoprotein B in patients with unstable angina pectoris,and the clinical significance of two laboratory indexes in patients with unstable angina pectoris.It provides a new reference scheme for doctors’ clinical diagnosis and treatment.Materials and methods : This study collected 140 patients with unstable angina pectoris who were hospitalized in the Department of Cardiology of the Affiliated Hospital of Liaoning University of traditional Chinese medicine from March 2021 to December2021.There were 77 males and 63 females;The oldest patient was 75 years old and the youngest patient was 40 years old,with an average age of 64.44 ± 7.615.All patients who entered the study met the inclusion criteria.The selected patients were divided into five syndrome groups,including 62 patients with phlegm turbidity and blood stasis syndrome,44 patients with Qi deficiency and blood stasis syndrome,22 patients with qi stagnation and blood stasis syndrome,8 patients with Qi Yin deficiency syndrome and 4 patients with heart blood stasis syndrome.All selected patients should exclude serious primary diseases such as chest pain,acute infection,severe liver and renal insufficiency,severe heart failure caused by non heart diseases,tumor patients,patients with surgery history and major trauma in recent three months,severe arrhythmia and drugs that may affect the research results.Record the general clinical data of the selected patients,including gender,age,past medical history,smoking history,drinking history,etc.,carry out TCM Syndrome Differentiation for the patients,and record the TCM syndrome differentiation types of the patients.According to the TCM diagnostic criteria,all the selected patients are differentiated by the Chinese doctors at or above the deputy director.The syndrome types are complex and the dialectics are unclear,Then,two or more deputy chief TCM doctors will dialectic again and record the final dialectic results.The final dialectical results were divided into five syndrome groups: Qi stagnation and blood stasis syndrome,phlegm turbidity and blood stasis syndrome,Qi deficiency and blood stasis syndrome,Qi Yin deficiency syndrome and heart blood stasis syndrome.After admission,the patient immediately took blood routine,coagulation function,renal function,fasting or the next morning to collect venous blood for liver function,fasting blood glucose,blood lipid series,etc.All selected patients were graded for angina pectoris and evaluated for the total score of angina pectoris symptoms.The correlation between apolipoprotein A and apolipoprotein B in each group was compared by SPSS24.0 for statistical analysis.Results:1.Among 140 patients with unstable angina pectoris,the highest frequency of phlegm turbidity and blood stasis syndrome was 62 times(44.29%),followed by qi deficiency and blood stasis syndrome 44 times(31.43%),qi stagnation and blood stasis syndrome 22 times(15.71%),Qi Yin deficiency syndrome 8 times(5.71%),and heart blood stasis syndrome 4times(2.86%).Clinically,phlegm turbidity and blood stasis syndrome,Qi deficiency and blood stasis syndrome and qi stagnation and blood stasis syndrome are the main TCM Syndromes of unstable angina pectoris.2.The distribution of TCM Syndromes of unstable angina pectoris in male patients is: phlegm turbidity and blood stasis > Qi deficiency and blood stasis > qi stagnation and blood stasis >heart blood stasis > Qi and yin deficiency;The distribution in female patients is: phlegm turbidity and blood stasis > Qi deficiency and blood stasis > qi stagnation and blood stasis >deficiency of Qi and Yin > heart and blood stasis.However,there was no significant difference between different gender in different TCM syndrome types(P > 0.05).3.According to each syndrome type of traditional Chinese medicine,the largest average age is heart blood stasis syndrome(70.25 ± 5.123),followed by qi deficiency and blood stasis syndrome(66.60 ± 5.270),Qi Yin deficiency syndrome(66.25 ± 6.497),phlegm turbidity and blood stasis syndrome(62.55 ± 7.062)and qi stagnation and blood stasis syndrome(62.55 ±7.062).The average age of each TCM syndrome type is as follows: heart blood stasis > Qi deficiency and blood stasis > Qi Yin deficiency > phlegm turbidity and blood stasis > qi stagnation and blood stasis.The mean age of patients with phlegm turbidity and blood stasis was significantly different from that of patients with Qi deficiency and blood stasis(P = 0.016< 0.05),and the mean age of patients with qi stagnation and blood stasis was significantly different from that of patients with Qi deficiency and blood stasis(P = 0.04 < 0.05).4.The distribution of apolipoprotein A among different TCM syndrome types: Qi stagnation and blood stasis > Qi deficiency and blood stasis > heart blood stasis > Qi Yin deficiency >phlegm turbidity and blood stasis.There was significant difference in apolipoprotein A between phlegm turbidity and blood stasis syndrome and Qi deficiency and blood stasis syndrome(P = 0.043 < 0.05),and there was significant difference between phlegm turbidity and blood stasis syndrome and qi stagnation and blood stasis syndrome(P = 0.029 < 0.05).The distribution of apolipoprotein B among different TCM syndrome types: phlegm turbidity and blood stasis > Qi and yin deficiency > heart and blood stasis > qi stagnation and blood stasis > Qi deficiency and blood stasis.There was significant difference in apolipoprotein B between phlegm turbidity and blood stasis syndrome and Qi deficiency and blood stasis syndrome(P = 0.03 < 0.05),and there was significant difference in apolipoprotein B between phlegm turbidity and blood stasis syndrome and qi stagnation and blood stasis syndrome(P =0.023 < 0.05).5.There was significant difference in the number of smoking between men and women with Qi deficiency and blood stasis syndrome(P = 0.032 < 0.05),and there was no significant difference in the number of drinking among TCM syndrome groups(P > 0.05).6.There was significant difference in the mean of apolipoprotein A between different sexes(P= 0.003 < 0.05),and there was no significant difference in the mean of apolipoprotein B between different sexes(P = 0.443 > 0.05)Conclusion:1.Clinically,phlegm turbidity and blood stasis syndrome,Qi deficiency and blood stasis syndrome and qi stagnation and blood stasis syndrome are the main TCM syndrome types of unstable angina pectoris,and the number of patients with phlegm turbidity and blood stasis syndrome is more than that of other groups2.The values of apolipoprotein A and apolipoprotein B are different among different TCM syndrome types,and the value of apolipoprotein B in patients with phlegm turbidity and blood stasis syndrome is higher than that in other groups.To a certain extent,it reflects the differences and characteristics among TCM syndrome types.3.The distribution of apolipoprotein A was different between different sexes. |
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