A Preliminary Study On The Correlation Between Homocysteine, Serum Cholinesterase And Cold-heat Syndrome Differentiation Of Coronary Heart Diseas

Research objectives:The general situation,clinical data and TCM syndrome differentiation of 167 patients with coronary heart disease were collected and analyzed.The objective indicators of western medicine laboratory were incorporated into TCM syndrome differentiation system,so as to promote the organic integration of Chinese and Western medicine,enhance the objectivity of TCM clinical syndrome differentiation,and improve the accuracy of TCM syndrome differentiation of coronary heart disease.To explore and analyze the relationship between CHD syndrome type and blood lipid,homocysteine and serum cholinesterase,in order to provide objective basis for TCM syndrome differentiation of CHD patients.Research Methods:According to the inclusion criteria,167 cases of patients with coronary heart dise ase were included as the observation group,and 60 cases of physical examination in t he physical examination department of the Third Affiliated Hospital of Beijing Univers ity of Chinese Medicine and Fangshan Hospital of Chinese Medicine in the same peri od were included as the control group.According to the "Traditional Chinese medicine new medicine clinical research guiding principle ","standard of disease diagnosis curat ive effect of traditional Chinese medicine" for the diagnosis of obstruction and the co mbination according to the coronary heart disease cold-heat syndrome types formulate d by the diagnostics of TCM dialectical criteria for the diagnosis of questionnaire surv ey,collection and coronary heart disease(CHD)in patients with TCM four diagnostic i nformation,by two heart medicine of traditional Chinese medicine experts(subtropical high and above the title)for the patient to syndrome differentiation of traditional Chin ese medicine,They were divided into heat syndrome group,cold syndrome group and mixed cold and heat syndrome group.Collected the patient’s general data,such as ge nder,age,height,weight,BMI calculation,drinking,smoking,the history of diabetes and high blood pressure,serum total cholesterol(TG),low density lipoprotein(LDL-C),hi gh density lipoprotein(HDL-C),triglyceride(TC),apolipoprotein A1(ApoAl),apolipoprotein B(ApoB),lipoprotein a[LP(a)],homocysteine(Hcy),serum cholinesterase(CHE)and other laboratory physical and chemical indicators,database was established,and SPSS26.0 so ftware system was used for data analysis,to analyze the correlation between TCM col d-heat syndrome types of coronary heart disease and other objective information.Results:1.There were no statistically significant differences in age,gender,ApoB and LP(a)between the observation group and the control group(P>0.05);there were no statistically significant differences in BMI,history of alcohol consumption,history of smoking,history of diabetes,history of hypertension,TC,TG,LDL-C,HDL-C and ApoAl(P<0.05);There were no significant differences in TC,TG,LDL-C,HDL-C,ApoA1,ApoB and LP(a)levels among the observation group(P>0.05).2.The level of Hcy in the observation group was significantly higher than that in the control group.In correlation analysis,the level of Hcy was positively correlated with TC(P<0.01)and LDL-C(P<0.01).3.The serum CHE level in the observation group was significantly higher than that in the control group.In correlation analysis,the serum CHE was positively correlated with TC(P<0.01),TG,LDL-C and ApoAl(P<0.05),and ApoB(P<0.01).4.In the observation group of 167 CHD patients,the heat syndrome group accounted for 44%,the cold syndrome group accounted for 31%,and the cold and heat mixed group accounted for 25%,and the heat syndrome group accounted for the highest proportion.5.There were statistically significant differences in blood Hcy levels among CHD patients with HHcy heat syndrome group,cold syndrome group and mixed cold and heat group(P<0.05).There were statistically significant differences in blood Hcy levels between the heat syndrome group and the cold syndrome group,and between the heat syndrome group and mixed cold and heat group(P<0.05).There was no significant difference between the group with mixed cold and heat syndrome and the group with cold syndrome(P>0.05),and the blood Hcy level showed the trend distribution of the group with hot syndrome>mixed cold and heat syndrome>cold syndrome.6.There were statistically significant differences in serum CHE level among CHD hea t syndrome group,cold syndrome group and mixed cold syndrome group(P<0.05).There were statistically significant differences in serum CHE level between heat syndrome gr oup and cold syndrome group(P<0.05),while there were no statistically significant diff erences between mixed cold syndrome group and mixed cold syndrome group and mix ed cold syndrome group(P>0.05).The serum CHE level showed the trend distribution of hot syndrome>mixed cold and heat syndrome>cold syndrome group.Conclusion:1.Hcy and serum CHE were significantly increased in patients with CHD,and were correlated with some blood lipid levels,suggesting that there was a relationship between Hcy and serum CHE metabolism and blood lipid,and that the two were also correlated with the occurrence and development of CHD.2.In the results of syndrome differentiation of CHD with HHcy,the Hcy level in the heat syndrome group was significantly increased,and Hcy showed a trend of hot syndrome>mixed cold and heat syndrome>cold syndrome group,suggesting a correlation between the Hcy level and CHD with HHcy heat syndrome.3.In the results of CHD syndrome differentiation,CHE level in the heat syndrome group was significantly increased,showing a trend of hot syndrome>mixed cold and heat syndrome>cold syndrome group.suggesting a correlation between CHE and CHD with HHcy heat syndrome.