| Purpose:This study analyzes and explores the advantages and value of Xinmailong Injection by observing its clinical efficacy in combination with Western medicine in the treatment of chronic heart failure of Qi deficiency and blood stasis typMaterial and method:A total of 80 patients from the First Department of Cardiology of Liaoning University of Traditional Chinese Medicine were randomly divided into experimental group and control group,with 40 cases in each group.The control group was given conventional western medicine treatment,diuretics,β-blockers,vasodilator drugs(sodium nitroprusside,nitroglycerin)and other symptomatic conventional treatment.On the basis of routine treatment,the experimental group was treated with Xinmailong injection.The usage was as follows: Xinmailong injection(5 mg/kg each time)was diluted to 50 m L in 5%glucose injection or 0.9% sodium chloride injection.The drug was given by intravenous pumping at a speed of 18-20 m L/h,twice a day,with an interval of at least 6 hours,for a total of 10 days.Clinical observation was carried out after 10 days of treatment: the changes of indicators in the experimental group and the control group before and after treatment were observed,and the indicators were as follows :1.Left ventricular ejection fraction(LVEF),left ventricular end-systolic diameter(LVESd),left ventricular end-diastolic diameter(LVEDd),4.6 minute walking distance(6MWD),5.B-type natriuretic peptide(BNP),6.The TCM symptom score was evaluated 12 months after discharge.Finally,the collected data were statistically processed by SPSS26.0 software.For the count data that conformed to the normal distribution,the independent sample t test was used,and the method was expressed as mean ±standard deviation.For the count data that did not meet the normal distribution,the nonparametric rank sum test was used,and the method was expressed as the median(25% quartile,75% quartile),namely M(Q25,Q75).The enumeration data with two items in the form of constituent ratio were tested by four-fold table chi-square test to express the number of cases and percentages.Results:1.After treatment,the TCM syndrome score and B-type natriuretic peptide of the experimental group and the control group were significantly lower than those before treatment(p<0.05),and the reduction effect of the experimental group was more obvious than that of the control group(p<0.05).2.The left ventricular ejection fraction and 6-minute walk distance of the experimental group and the control group were significantly increased after treatment(p<0.05),and the experimental group was more effective than the control group(p<0.05).3.After treatment,the heart function grading,left ventricular end systolic diameter,left ventricular end diastolic diameter,and traditional Chinese medicine syndrome scores of the experimental group and the control group decreased compared to before treatment,but there was no statistical difference(p>0.05).4.After treatment,the total efficacy and efficiency of patients in the experimental group were higher than those in the control group,but there was no statistical difference(p>0.05).Conclusion:1.Xinmailong injection can improve the symptoms and signs of patients with chronic heart failure of qi deficiency and blood stasis type.2.Xinmailong injection can improve left ventricular ejection fraction and 6-minute walking distance in patients with chronic heart failure of qi deficiency and blood stasis type3.After treatment with Xinmailong Injection,the patient’s heart function grading,traditional Chinese medicine syndrome score,BNP,LVEDd,and LVESd can be reduced,and the combined treatment with Xinmailong has a more significant effect on reducing BNP and traditional Chinese medicine syndrome score.4.The therapeutic effect of Xinmailong injection on patients with chronic heart failure is significant and has no significant adverse reactions,which has clinical value.However,further research is needed to explore the prognosis and efficacy of Xinmailong injection. |
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