Clinical Observation On The Treatment Of Large Intestine Damp-heat Syndrome In Ulcerative Colitis With Jiawei Tongfu Mixture Combined With Yichang Enema Solutio

Purpose:By analyzing the Jiawei Tongfu decoction combined with Yichang Guanchang decoction before and after treatment in patients with ulcerative colitis symptoms and quality of life improved,the clinical efficacy of Jiawei Tongfu decoction combined with Yichang Guanchang decoction in the treatment of large intestine damp-heat ulcerative colitis was observed,and its effectiveness was comprehensively evaluated.Material and method:Sixty-eight patients diagnosed with mild or moderate active ulcerative colitis in the Affiliated Hospital of Liaoning University of Traditional Chinese Medicine from September 2021 to December 2022 were randomly divided into the traditional Chinese medicine group(34 cases)and the western medicine group(34 cases).The patients in the TCM group were treated with Jiawei Tongfu decoction 100 ml twice a day and Yichang Guanchang decoction enema 50 ml once a day.The western medicine group was given mesalazine sustained-release granules 1g orally,3 times a day,and the suppository mesalazine was given anal insertion once a day.The course of treatment was 28 days.Results:1.A total of 68 patients who met the inclusion criteria were included in this study,including 34 patients in the traditional Chinese medicine group and 34 patients in the western medicine group.During the experiment,4 patients dropped out of the traditional Chinese medicine group and 4patients dropped out of the western medicine group.Finally,60 patients were observed,30 patients in the traditional Chinese medicine group and 30 patients in the western medicine group.2.Before treatment,the gender,age,course of disease,severity of disease,modified Mayo score,TCM syndrome score,and quality of life evaluation were compared between the two groups,and there was no significant difference in the scores between the two groups(P>0.05),which was comparable.3.The comparison of the scores of main and secondary symptoms of traditional Chinese medicine between the two groups before and after treatment showed that both the traditional Chinese medicine group and the western medicine group could improve the main and secondary symptoms of UC patients with large intestine damping-heat type(P<0.05),but the improvement of the main and secondary symptoms of the traditional Chinese medicine group was significantly better than that of the western medicine group(P<0.05).In addition,the traditional Chinese medicine group had more advantages in improving the main symptoms and secondary symptoms of UC patients,such as short or yellow urine,dry mouth,bitter mouth or thirst(P<0.05).There was no statistical significance in the improvement of abdominal distension between the two groups(P>0.05),indicating that the improvement of abdominal distension between the two groups was similar.Western medicine group is better than traditional Chinese medicine group in improving anal burning(P<0.05).4.The comparison of the improved Mayo score between the two groups before and after treatment showed that both the traditional Chinese medicine group and the western medicine group could effectively reduce the improved Mayo score in UC patients(P<0.05),but the traditional Chinese medicine group had more advantages in reducing the Mayo score(P<0.05).5.The comparison of the quality of life evaluation between the two groups before and after treatment showed that both the TCM group and the western medicine group could improve the quality of life in the fields of physiology,independence,psychology and social environment of UC patients(P<0.05),and the TCM group was better than the western medicine group in improving the quality of life in the fields of independence,psychology and social environment of UC patients(P<0.05).In terms of improving the quality of life in physiological field,the two groups had similar effects(P>0.05).6.After treatment,the efficacy of TCM syndrome in the two groups showed that the number of clinical effective cases in the TCM group was 28,and the total effective rate was 93.33%.The number of clinical effective cases in the western medicine group was 26,and the total effective rate was 86.67%.The rank sum test between groups showed P<0.05,indicating that the traditional Chinese medicine group had more advantages in improving the TCM syndrome.After treatment,the comprehensive efficacy evaluation of the two groups of patients showed that the number of effective cases in the Chinese medicine group was 27,and the total effective rate was 90%,while the number of effective cases in the western medicine group was 21,and the total effective rate was 70%.The comparison of rank sum test between groups showed that P<0.05,indicating that the Chinese medicine group was superior to the Western medicine group in the evaluation of comprehensive efficacy.7.During the treatment,there were no obvious abnormalities in blood pressure,pulse and respiration of patients in the two groups,and no discomfort symptoms such as drug allergy and anal skin and mucosa damage occurred.Conclusion:Both Jiawei Tongfu decoction combined with Yichang Guanchang decoction and Mesalazine sustained-release granule combined with Mesalazine suppository have therapeutic effects on UC patients with large intestine damping-heat type,but the therapeutic effect of Jiawei Tongfu decoction combined with Yichang Guanchang decoction is better than that of the western medicine group.It has more advantages in improving the symptoms of diarrhea,mucus,pus and bloody stool,abdominal pain,tenesmus and anal burning,short or yellow urine,dry mouth and bitter mouth or thirst,reducing Mayo score and improving the quality of life of patients in the field of independence,psychology and social environment,which can be widely used in clinical practice.