Study On Genetic Basis Of Abnormal Behaviors In Mice

Animals displayed many abnormal behaviors in constraint environment and confined production conditions. Many scholars considered that the appearance of abnormal behaviors indicate the unsuitable living environment. In this study abnormal behaviors of mice and their genetic basis were systematically observed. Quantitative genetics were chose to estimate the heritability of these behaviors. The relationship of the level of cortical hormone and the abnormal behaviors was also studied.1 The research of abnormal behaviors and normal behaviors of mice.The environment included a commercial home-cage and a glass cage. Kunming mice were used in experiment. Four generations were observed and breed. The computer monitoring photographic recording was used to observe these young female mice for 24 hours. The abnormal behaviors included cage top creeping, swing, jumping and backward somersaulting. The normal behaviors included sleeping, drinking, eating, looking, decorating, pacing, digging, searching, grinding teeth and windscreen wiper movements.After two weeks 16 female mice were chose which displayed conspicuous abnormal behaviors as jumping group, 16 female mice were chose which displayed very few abnormal behaviors as non-jumping group. The study methods of F1,F2 and F3 generations were as same as their parential generation.The result showed that all frequency and periodicity of abnormal behaviors of F1, F2 and F3 generations were more than their parential generation. In the four generations the frequency and periodicity of abnormal behaviors of the jumping groups were more than the non-jumping groups. The time of sleep for the non-jumping groups and the control group were longer than the jumping groups .The time of sleep of the jumping group of parential generation were longer than the jumping groups of F1, F2 and F3 generations. The frequency of decoration of the non-jumping groups was higher than the jumping groups. The frequency of exploratory behavior for the jumping groups was higher than the non-jumping groups and the control group. Other normal behaviors of four generations jumping group showed no significant difference. The time of sleep was during 6:00 to 14:00 and the abnormal behaviors occurred during 20:00 to 24:00. The abnormal behaviors of the jumping mice happened earlier than others.