Computer Simulation On Pulsatile Heart And Its Construction Using The Distributed Software Architecture

The electrical heart model plays a key role in the research work of forward problem and inverse problem in electrocardiograph (ECG). At one hand, new physical and physiological knowledge of human heart keep being used to construct the heart model, and at the other hand, the scholar of inverse problem eager to obtain a heart model as precise as possible which can be employed to study the characteristic symptom of pathological heart. As a result of all these, to build an ideal heart model become many scholars' research emphases. To improve the precision of electrical heart model, cardiac researchers have investigated many methods: they divide heart model into much tinier myocardial units, employ much more complicate excitation propagation simulation algorithm and assume much shorter excitation step than ever. Or, they consider the inhomogeneous torso and the myocardial anisotropy and the existence of the human lung and then introduce these factors into their electrical heart models. Those methods do take effect more or less, but at last the heart model itself still has unavoidable errors.Human heart, which is known as the center of the cardiovascular system, should be understood as a complex synthesis that is integrated with electrical, mechanical, neural, and biochemical properties. So, if we want to build an ideal heart model, we shouldn't limit our viewpoint within the separate electrical or mechanical area although its function is simulating the electrical or mechanical activity of human heart. For a long time, the effort to construct a composite heart model hasn't resulted any significant achievement because of the inherent complexity of many related areas of heart research and the limitation of the computer capability. Recent study at the cardiomechanic area reveals many important mechanisms of human heart and constant innovation in computer hardware and software nowadays brings us the unprecedented computational capability. And more, some advanced iatrical-imaging technologies such as tagged MRI etc. have appeared at recent days. All these progresses made it possible to build an electrical-mechanical composite heart model. Based on the research work of Biomedical Institute of Zhejiang University in the past decade, this article launch on this project. The traditional electrical heart model has been reconstructed to reflect the mechanical property firstly, and then we introduce the mechanical deformation data, which is produced by the tagged MRI and the mechanical heart model, into the electrical heart model to adjust the displacement of the equivalent dipole during one cardiac cycle. Therefore, an elementary electrical-mechanical composite heart model- pulsatile heart model is built at the first time in the world. After that, we use the new model to simulate the ECG and BSPM of the normal heart and the pathological heart and then compare its output with the original heart model's. The result substantiates the importance of the mechanical factor in the construction process of heart modeling. Moreover, this article proposes new software technology-distributed software architecture to redesign the heart model at last.In this article, the author has done the following research work:? The methodologies and developments of the previous electrical heart modeling are reviewed and the meaning and limitation existing in them are analyzed in detail. Based on these discussions, the author point out that all these methods belong to the "static" heart modeling and thus have the unavoidable output errors.? The methodologies and developments of the previous cardiomechanics are reviewed and the meaning and limitation existing in mechanical imaging methods and mechanical heart modeling are analyzed in detail.? The traditional electrical heart model has been reconstructed to reflect the mechanical property firstly, and then we introduce the mechanical deformation data, which is produced by the tagged MRI and the mechanical heart model, into the electrical heart model to adjust the displacement of the equ...