| Insulin resistance(IR) refers to the state in which the function of normal dosage of insulin is much lower than expected, it is also called insensitivity to inslin. In the last few years, research has shown a relationship of IR to many kinds of illness(such as: Coronary-Artery-Disease; essential Hypertension; Diabetes mellitus; Obesity; Cerebral diseases,etc.), and that IR may even be the foundamental cause of the above diseases. Therefore research concerning IR has become a heated subject in the realm of present day medical research. This is especially true of research concerning its etiology and intervention. Not only is a new avenue being opened up for thought concerning effective treatment but also for the clinical treatment of many diseases which have a relationship to IR. The natural nature of Acupuncture has for several thousand years had an important role as a treatment method because it is uncomplicated, economical, convenient and efficacious. Much modern research has confirmed its role in the regulation of the endocrine and neurotransmitter systems, thereby facilitating the guadual appearance of its superiority in the treatment of many modern diseases. Although there has been little application of Acupuncture in the treatment of IR, its application in the treatment of Diabetes mellitus, Obesity and CVAs is widelyacknowledged. Therefore this thesis is based upon these various investigations with emphasis upon the application of Acupuncture in the intervention of IR. There are three sections: research literature ; experimental study and a summary. I . Research literatureIn this section a comprehensive summary of research literature concerning IR from the IR prospective as well as it relationship to other disease is conducted. The etiology, analysis of the present condition of research and Chinese herbal prevantion are also ecxpounded upon. Special emphasis is applied to the critique of domestic research concerning the use of Acupuncture in the treatment of IR. With commentary upon past and future directions of research we put forth that Acupuncture be considered an effective form of treatment for IR and that further investigation should be conducted into the mechanism of its effects upon IR. II. Experimental ResearchIn this experiment, rats were raised on a high sucrose diet inducing them into a state of IR. We observed the application of Acupuncture on Fasting Plasma Glucose (FPG), Fasting Plasma Insulin (FINS), the Insulin Sensitivity Index (ISI), Insulin receptors, Antibodies to Insulin, Factor Alpha (TNF- a ) and GLUT4. The results showed:1. After raising the experimental rats on a high sucrose diet for 35 days, the FPG, FINS and Insulin C-peptide ( INS/C-p ) were higher than that ofnormal rats(P<0.01) and the ISI was lower than that of normal rats(P<0.01). This indicated that the experimental rats had become resistant to insulin. After the application of Acupuncture for 10 days, the FPG, FINS and INS/C-p levels diminished significantly. The ISI also clearly improved which proved that Acupuncture could improve the state of IR in experimental rats.2.In an experiment to determine the fixation rate of antibody to insulin, we found that whether it were "IR rats" of normal rats the fixation rate was zero. After therapy with Acupuncture the positive Fixation rate didn't change, which indicated that the improvement Acupuncture application displayed in other experiments was not due to an increased antibody fixation to insulin.3. In an experiment to determine insulin receptors ability to respond to insulin, it was shown that Acupuncture promoted response. The increased response of insulin receptors to insulin increased insulin's biologic effect.4. By contrast TNF-a in muscle, blood and adipose tissue of "IR rats" as compained to normal rats was found to be much higher(P<0.01...
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