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Study On The Pathological Mechanism Of The Syndrome Of Phlegm And Blood Stasis In Atherosclerosis

Posted on:2003-02-06Degree:DoctorType:Dissertation
Country:ChinaCandidate:D S WangFull Text:PDF
GTID:1104360065460996Subject:Diagnostics of Chinese Medicine
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Objective:l.To expound the distribution of characteristics of clincal syndrome in atherosclerosis(AS).2.To expound the law of pathological development of the Syndrome of phlegm and bood stasis in As.3.To expound the mechanism of the syndrome of phlegm and blood stasis in AS.Methods:1.Literature research: To investigate systemicaly the related literature on As in ancieut and modern times and sum up its background.2.Epidemiology investigation on AS: To adopt the multicenter,maximus sample clinical survey.3.Related indexes of the syndrome of phlegm and blood stasis in As:blood lipid,blood sugar,insulin,insulin sensitive index,hemorheology, and optic, electron microscope,etc.4. Study on the related mechanism of the syndrome of phlegm and blood stasis in As:To detect the apoptosis and signal transmission of actin of aorta with immunocytochemistry and the related gene expression with RT-PCR.5.To treat As with traditional Chinese medicine of resolving phlegm and promoting blood circulation in rats,detect the indexes mentioned above ,and certificate the pathological mechanism of the syndrome of phlegm and blood stasis in As.Results:1 .Literature research showed As was non-inflammatorily ,regressively andhyperplasticaly pathological changes of artery. Its basic pathological mechanism was deficiency in origin which is deficiency of Qi,blood,ym and yang,and excess in superficiality which is accamulation of phlegm and blood stasis.Its pathological change was characterized with deficiency in origin and exces in superficiality caused by the vicious cycle of excess caused by deficiency and deficiency caused by excess.The pathological key was the accumulation of phlegm and blood stasis.2.Epidemiological research in 310 cases of coronary heart disease showed that the syndrom of phlegm and blood stasis occupied 70.3%,the syndrome of deficiency of Heart-Yang and kidney-yang 8.4%,the syndrome of deficiency of Heart-Yin and kindey-Yin 6.5%,the syndrome of obstruction of the heart collaterals and vessels due to 7.0%,respectively the microchange of the syndromes of obstruction of blood vessels due to accumulation of phlegm the abnormality of blood-Lipid.Biochemical change of the syndrome of obstruction of phlegm and blood stasis was the abnormality of hemorheology of phlegm and blood stasis was the abnormality of hemorheology associated with the alteration of tissue constructer,which had coronary shadow showed severe multi-ramus constriction and transparent atheromatous plaque,which were severe synptoms of CHD.There was insulin resistance in the process of changes from health to the syndrom of non-phlegm and non-blood stasis to the syndrome of obstrustion of blood vessel to the syndrome of obstructon of phlegm and blood stasis in CHD.The expression of c-myc mRNA,PDGF-AmRNA of blood corpulse in patients with coronary heart disease increased by tums,and the phlegm and blood stasis existed all through the pathological process of CHD.3.Animal experiment confirmed the clinical findings mentioned above.In addition,the expression of c-mycmRNA,PDGF-AmRNA,c-fosmRN/^, bcl-2mRNA increased abnormally and the expression of P53 mRNA decreased ,and the expression of actin and apoptosis increased step by step.The stage of phlegm and stasis was the quantitative change procedure of stack of pathological substances, and the obstraction of phlegm and blood stasis was caused by changes of associated cellular tissue constitution and function.4.The METhod of resolving phlegm and promoting blood circulation had a better effect on As with the traditional Chinese medicine.in rats(l)In whole level , it could decrease Lipid-blood,improve hemorheology,and alter insulin resistance.(2)In the organ and tissue level, it could protect the structure of arterial tissue,keep its function stabilized and fadeaway and reverse hyperplastic plaque of arterial tissue.(3)In the cell level,it could protect the structure and function of blood vessel smooth muscle cell, and keep apoptosis equilibrium.(4)In the molecular leve...
Keywords/Search Tags:Atherosclerosis, phlegm and stasis of pathological/Traditional Chinese medicine, dissipating phlegm to activate blood/Traditional Chinese medicine, lipid-bloodl, hemorheology, insulin Resistance, poptosis, actin Gene expression
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