Clinical And Experimental Study Of Zheng Xin Tai Decoction For Acute Myocardial Infarction

In order to extend the treatment range of Zhengxintai,a complex prescriptions of supplementing vital energy and activating blood circulation used to treat coronary heart disease and cardiac angina. Based on aboveapplication,we use it to treat acute myocardial infarction(AMI). According pathogenesis of acute myocardial infarction,deficiency of vital energy and blood stasis is a common pathogenesis of this kind of disease.Using the Zhengxintai tablet adding routine western medicine to treat 30 cases AMI,compared the effects with 29 cases of the same disease treated merely by routine western medicine .The results showed,the effects of combined Zhengxintai with western medicines are better than controlled team by western medicine at the amelioration of total body symptom. picture of the tongue. type of pulse,etc. The Zhengxintai can decrease the blood fat level of acute myocardial infarction,ameliorate hemorheology and left ventricle cardiac funtion;and decrease the positive rate of ventricle late potential .Animal experiments showed,that Zhengxintai has the effect of anti-oxidation decreasing theblood serum malondialdehyde(MDA) leveK increasing the superoxide dismutase(MDA) leveK increasing blood serum nitrogen monoxide(NO). regulating gene expression level of nitricoxide synthase(NOS) in myocardium cell and endothelium cell decreasing blood serum endothelins(ET) level and regulating its gene expression. So it is showed that Zhengxintai can protect ischemia myocardium cell.