Experimental Study On Treatment Of Ongestive Heart Failure With The Therapy Of Invigorating Yang-Qi And Promoting Blood Circulation And Resolving Dampness

Objective: To detect the main pathogenesis of CHF and find an effective medicine to prevent the development of CHF and decrease its fatality in herbs.Materials and methods: 75 Wistar rats were devided into 5 groups at radom,15 rats per group.They are normal group,model group,preventive treating group,treating group and contrasting group.The rat model of CHF was created by injection ADR in abdomen for 6 weeks, once a week.The preventive treating group and treating group were given Qiangxin Capsule(QXC) composed of ten herbs including of Ginseng,Prepared Aconite Root and so on.The contrasting group were gave Betaloc and Captopril.After giving drugs for 4 weeks(treating group and contracting group) and 6 weeks(preventive treating group ),all rats' heart function were measured by 8-leads mechanocardiography .Then the circulatory level of Ang II ,ANP,Ald,ET,TNF- a in blood of rats were studied.Results: QXC can improve heart function of CHF rats,it can also decrease the level of Ang II ,ANP,Ald,ET,TNF- a in blood.QXC can prevent rat heart cells from apoptosis through adjusting releated genes.Finally the damage in rats' heart were leveaited by QXC.Conclusion: Dificiency of yang-qi with blood stasis and phlegm is the main pathogenesis of CHF.Invigorating yang-qi, promoting blood circulation and resolving dampness are valid therpy to CHF.QXC is an effective drug in treating CHF.