Association Between The Genetic Polymorphisms Of IL-4,β₂AR Gene And ECP,IgE With Bronchial Asthma In The Uygur Population

I Association between serum measurements of ECPx T-IgE and S-IgE with bronchial asthma in the Uygur populationBackground The accumulating knowledge during recent years has clearly indicated that one important cause of bronchial asthma is a kind of allergic and chronic inflanimation of the airway. In most instances the histopathology of this inflammation is characterized by the presence of an increased number of eosinophilic granulocytes. In particular, this seems to be true in the allergic type of asthma. Other causes of asthma way, in addition, involve other inflammatory cells such as the neutrophil. The role played by the eosinopb.il in the lung of the asthmatic patient is still not entirely clear. Although some data would indicate that these may be seperative in the process of epithelial shedding, either by a cytotoxic mechanism directed against the epithelial cells by the disruption of the structures necessary for the cells together. Other possibilities include a role in bronchoconstriction due to the production of leukotrienes and platelet-activating factor and the induction of glandular hypersecretion by ECP. Instrument in defining a role of the eosinophil in asthma have been studies employing broncho-alveolar lavage and biopsies of asthmatic subjects. Biopsy studies have shown the presence of activated eosinophils in the asthmatic lung and the disappearance of these cells after successfultreatment of asthma with inhaled corticosteroids. Similarly, lavage studies have shown a correlation between eosinophil numbers and ECP levels in the broncho-alveolar lavage on the one hand and the severity of asthma on the other. In addition, the studies showed a reduction in these variables by successful treatment. It should be emphasized that ECP levels were the only variables measured that, in these studies, consistently change is parallel with clinical improvement.The clinical management of asthma includes the monitoring of lung function and the anamnestic monitoring of the activity of daily living .It is well agreed that these measures are very often insufficient and do not accurately reflect, the underlying process of asthma, i.e. the extent of the inflammatory process. This is probably of the greatest importance, since it is well established that it may even be dangerous to treat the patients with symptomatic medication exclusively without controlling the underlying inflammayory process. The problem, however, is how to reflect accurately the inflammatory process of the asthmatic lung. Commonly used indicators of inflammatory activity such as blood ESR and acute-phase reactants in plasma are not altered in asthma.For some years we have been developing and testing the concept that the measurement of specific markers of various inflammatory activity in the body more sensitively than those tests commonly available today, and that such measurement would also provide unique information as to the underlying pathophysiological process of the disease. Until now we have developed assays specifically to reflect neutrophil activity [i.e. myeloperoxidase (MPO) and lactoferrin], eosinophil activity [i.e.ECP, eosinophil protein /eosinophil-derived neurotoxin (EPX/EDN)], eosinophil peroxidase (EPO)], and macrophage activity (i.e. lysozyme). These assays could be supplemented by tryptase specifically to reflect mast cell activity.Objective To explore serum ECP, T-IgE and S-IgE levels of Xinjiang-10-Uygur population, to study the correalation and their clinical significance in asthmatic patients in different degrees, and to elucidate the role of ECP and IgE in the pathogenesis of bronchial asthma.Methods 123 Uyger asthmatics and 89 normal healthy controls with the same ethnic nearby Xinjiang Hetian region were investigated. The serum ECP and total IgE and specific aeroallergen were detected using a pharmacia UniCAP 100 type instrument, pulmonary ventilatory function assessed by FEV₁ and PEF.Results The positive rate of specific IgE antibody in asthmatics was 17.89%(22/123). The inc...