Relationship Between Genetic Polymorphisms Of β₂-adrenergic Receptor And Infants Bronchiolitis Of Han And Uighur

Objective:Understanding the relationship between genetic polymorphisms ofβ₂-adrenergic receptor and infants bronchiolitis. Methods:The total DNA in the infantsbronchiolitis of Case group （n=131） and infants of Control group （n=110） were used astemplates, amplified β₂-adrenergic receptor gene by PCR, detected the gene by DNAsequencing technology, compared the similarity of sequencing results and NCBI genebank by BLAST. Results:There is significant difference in the frequencies of genotypes ofHan and Uighur children β₂-AR16loci in Case group （P＜0.05）, but it’s no significantdifference in control group. There is significant difference in the frequencies of genotypesand alleles of Han children β₂-AR27loci between the two groups （P＜0.05）. There issignificant difference in the frequencies of genotypes and alleles of β₂-AR16loci betweenthe two races （P＜0.05）. There is no significant difference in the frequencies of genotypesand alleles of β₂-AR between the sex （P＞0.05）. Conclusion:Race has correlation withgenetic polymorphisms of β₂-adrenergic receptor. Sexes don’t have correlation withgenetic polymorphisms of β₂-adrenergic receptor.