Studies Of Langchuangjing Granule Curative Effect To Lupus Nephritis's Active Stage

One of the key ways to prevent Lupus Nephritis(LN) developing to end stage renal failure is to effectively control the activity of LN. Also, effective immune interfere therapy is an important way to control activity of LN. The study aims to observe Langchuangjing Granule (LG) curative effect to LN's active stage and affection on change of serum Intercellular adhesion molecule-1 (sICAM-1) , which is based upon discussing the character pathogenesis of TCM and the rule of Syndrome Differentiation in different stage of LN.First is to discuss the pathogenesis and therapeutic rules according to the clinic. We think asthenia of kidney is Ben and Heat-toxin is Biao. As fundamental pathology, Damp-heat and Blood-stasis are the key factors of developing of disease during the through course. Damp and turbidity are the signs of developing of disease. It appears Heat-toxin and Damp-heat are chief in active stage whereas asthenia of the Zang and Fu organ accompanied by invade pathogen in relief stage, and deficiency of Ying and Yang, deficiency accompanied by stasis or Damp-turbid at the latest stage of disease. Pathology must be excess type transform from deficiency type, deficiency type transform from excess type and the excess pathogen and deficient Vital Qi, Yin-deficiency harms Yang at last. Cleaning away heat, promoting diuresis, removing toxic material, protecting kidney and activating blood circulation to dissipate blood stasis must be the treating principles.Second is to put forward that Differential Diagnosis in different stage, according to investigating literatures and clinical respective studies, can manifest the rules of pathogenesis evolvement and the characters of clinical appearance better. The active stage can be divided into Heat-toxic type, fever duo to Yin-deficiency type and Damp-heat stasis type. The relief stage can be divided into Yin-deficiency of liver and kidney type, the deficiency of Qi and Yin type, the deficiency of Qi and blood type and Qi- or Yang-deficiency of spleen and kidney type while accompanied by Damp-heat, blood-stasis or Damp etc. Similar to any renal disease, the latest stage of LN can be divided into two categories of Yin- and Yang-deficiency type and Turbid-stasis impedes collaterals type.Last is to observe the changes of albuminuria, hematuria, renal function and SLEDAI integral fore while using LG to treat LN's active stage. Results indicate that LG can effectively reduce the SLEDAI integral, can relieve hematuria, ameliorate renal function and relieve the symptom of erythema, lumbago and weary, can relieve palpitation and hand-shaking, the side effects of hormone. We think LG can prevent developing of disease by restrain activation of T cells and restrict B cells from producing more self-antibody and by reduce the activity of cell factors such as sICAM-lto relieve inflammation.