Diffusion Tensor MR Imaging In Diffuse Axonal Injury-an Animal Experiment Study And Clinic Case Review

Part one: Diffusion tensor MR imaging in cat experimental diffuse axonal injury.Objective: This study was designed to evaluate the value of DTI in diagnosis DAI in an animal model of head injury. Materials and Methods: Utilizing a simple weight-drop device consisting of a 450g segmented brass weight free-falling from 2 m hight, Six cats were subjected to brain trauma group and 4 cats were enrolled as normal control group, MR Images were collected before,: immediately after and 1 day following the traumatic event and then compared with histology.Results: T1WI and T2WI demonstrate normal in both groups. The FA decreadsed 1 day later (0.530±0. 026) compare with that before trauma(0. 567 ± 0. 017, p<0. 05) in brain traumaic group. The DCavg of the traumatized tissues is 0. 650 ±0. 306×10-5 cm2/s , 0. 6278 ±0. 786 × 10-5 cm2/s . 0. 645 ± 0. 817 × 10-5 cm2 /s before, just after and 1 day post traumaic event. Axonal swelling, retraction ball and neuronal change can be found in trauma group.Conclusion: An experimental model of diffuse axonal injury in cats was made. These results suggest that the measurement of FA in DTI may have the potential for evaluation axonal damage in experimental model of diffuse brain injury in cats even when conventional T2WI, T1WI demonstrate normal.