Basic And Clinical Study Of Acute Spinal Cord Injuries And Hyperglycemia

This paper is designed to study the change of blood glucose, insulin and insulin receptors in rats following acute spinal cord injury (SCI), to research the effect of hyperglycemia on biochemical, pathological and neurobehavioral changes in rats following SCI, to detect biochemical, pathological and neurobehavioral changes in diabetic rats after SCI, to investigate the factors and changes of blood glucose levels in patients following cervical spinal cord injury. Result: Blood glucose level increases but insulin sensitive index and density of insulin receptors decrease in rats following SCI. Post-traumatic hyperglycemia increases endothelins-1 values but decreases superoxide dismutase activity in spinal cord of rats after SCI significantly. Hyperglycemia worsens neurological outcome in rats following SCI. The levels of vitamin E and total antioxidizing capability in spinal cord of diabetic rats are depleted significantly following SCI. The worsen recovery of neurological function were observed in diabetic rats after SCI. In clinic, the incidence rate of hyperglycemia post-injury is related to the severity of spinal cord injury and age. The more severe spinal cord injury, the higher is the blood glucose value. Conclusion: The blood glucose levels increase in rats following SCI, which may be related to insulin resistance. The decrease of the density of insulin receptors is more likely the important mechanism of the insulin resistance in animal following SCI. Hyperglycemia plays a bad role in the secondary damage to spinal cord. Diabetic rats have poor recovery of neurological function following SCI. Almost 68% of patients have hyperglycemia response during the first 7 day after cervical SCI.