Effects And Mechanism Of Magnesium Supplementation On Expression Of Insulin Receptor And Anti-oxidative Activity In Type2Diabetes Rats

Objective:To observe the effects of magnesium supplementation on expression levels of type2diabetic rats.Method:Type2diabetes rats were established by feeding with high-fat-diet and injecting streptozotocin(STZ). Rats were randomized into four groups. The high-fat-diets were administrated with magnesium at dosages of2000mg/kg (high magnesium group),1000mg/kg (medium magnesium group) and200mg/kg (low magnesium group). The model control group was fed only with high-fat-diet. The normal control group was fed with common diet. Fasting blood glucose, insulin, the expression levels of IR of pancreas and skeletal muscle, TG, magnesium ion concentration, T-AOC,SOD and MDA were detected after the4-week trial.Results:(1) Expression levels of IR of pancreas and skeletal muscle in high magnesium group were0.341±0.001and0.346±0.002, significantly higher than the model control group(P<0.05).(2) Fasting blood glucose and fasting insulin were17.45±0.63,18.95±0.60in high magnesium group, significantly lower than the model control group(P<0.05).(3) SOD, T-AOC and magnesium ion concentrations were101.92±5.40,10.85±0.59and0.701±0.019in high magnesium group, significantly higher than the model control group(P<0.05).(4) MDA and TG contents were5.61±0.37and0.947±0.069in high magnesium group, significantly lower than the model control group(P<0.05).Conclusion:Magnesium supplementation increased the expression levels of IR of pancreas and skeletal muscle.The mechanism may be improving glucose and lipid metabolism and improving the anti-oxidative activity.