The Impact And Underlying Mechanism Of Platelet-derived Growth Factor Receptor-alpha In The Formation Of Keloid

Objective: To investigate the impact and underlying mechanism of Platelet-derived growth factor receptor-alpha (PDGFR-a) in the formation of keloid. Methods: Detect the expression of PDGFR-a in human keloid fibroblasts in vitro and compare with that in normal skin fibroblasts;Observe the influence of PDGFR-a on fibroblast proliferation and collagen synthesis;Observe the inducement of activated PDGFR-a to the activation of intracellular ERK pathway. Results: The expression of PDGFR-a in human keloid fibroblasts is significantly higher than that in normal skin fibroblasts, and up-regulated PDGFR-a significantly promotes fibroblast proliferation and collagen synthesis because activated PDGFR-a can induce the activation of ERK pathway which involves in cell proliferation and collagen synthesis. Conclusions: Up-regulated PDGFR-a in keloid fibroblasts plays an important role in the formation of keloid.