Study On The Regulation Of Adipokines Expression Induced By Hypoxia And Oxidative Stress And Their Underlying Mechanisms

Obesity is causally associated with the development of insulin resistance, type II diabetes and cardiovascular diseases (CVD). Adipose tissue is now recognized to be an important endocrine organ, secreting a variety of bioactive factors, named adipokines, which are involved in energy metabolism, inflammatory response and cardiovascular functions. Aberrant production of adipose-derived adipokines, especially adiponectin (AD), plasminogen activator inhibitor 1 (PAI-1) and interleukin-6 (IL-6), is now believed to play a causative role in the development of obesity-associated insulin resistance and cardiovascular disorders. Previous study suggests that obesity may induce systemic oxidative stress (OS) and the increase of reactive oxygen species (ROS) in accumulated fat. Accumulating evidences highlight the notion that hypoxia may exist in fat depots as the fat mass increases. It is not very clear what roles the local hypoxia and OS play in the pathogenesis of obesity and obesity-related diseases. In this study, we investigated the effects of hypoxia and OS on production of three key ADS (AD, PAI-1 and IL-6), and explored the...