Primary Experimental Study Of Tissue-engineered Right Ventricular Valved Conduit Based On Acellular Bovine Jugular Vein

Current right ventricular outflow tract (RVOT) replacements have problems in terms of long-term implantation. Tissue valved conduit substitutes, including xenograft conduits and homograft conduits, have a much lower thromboembolism risk, but have an expectancy of only 10-15 years. These conduits have difficulties with the size matching for infants and children. One solution would be tissue engineering. Tissue engineering is based on the artificial or natural tissue decellularized scaffolds. Cultured autologous cells may be seeded onto the scaffolds prior to implantation and repopulated with the patient s cells in situ. A tissue-engineered right ventricular valved conduit containing living autologous cells would be able to maintain its histological and biological properties yet grow in infant or child.Bovine jugular vein (BJV) contains natural valves. The leaflets of the valve are extremely thin and mobile. The venous vessel wall is soft and ideal for suturing. Moreover, its availability in various diameters from 12 to 22 mm makes its use possible in infants and children. However, the decellularized methods...