| Background & Objective: Many previous studies showed that c-sensory nerve fibers took part in repair of cutaneous trauma by synthesizing and releasing sensory neuropeptides (SNP). As a vital kind of SNP, substance P (SP) may be endowed with great abilities boosting skin regeneration and wound repair. Until now, whether SP amounts in different wounds are relative to their diverse healing potencies is not clear. Furthermore, the effects of SP on fibroblasts (FB) functions may also contribute to the formation of pathological scars. The mechanisms of SP effects throughout wound repair are not elucidated entirely. So we designed this study to explore the relationship between SP and wounds healing in the early stage and scars formation in the following stage.Methods: in vivo: Various-thickness-scalded Wistar rats were employed to determine the SP amounts in wounds tissues by means of radioimmunoassay at 1, 3, 7, 14 day postburn respectively, in vitro: MTT or FCA method was applied to examine the activities or apoptotic rates of granulation tissue fibroblasts (GTF) and fibroblasts derived from keloid...
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