The Relationship Between Biological And Their Phenotypic Properties Of Wound Healing Fibroblasts And Scar Formation In Human Skin After Deep Partial-thickness Burn Injury

Hypertrophic scarring and scar contracture are the main complications that often follow thermal injury, which are the most important factors destroying patients' cosmetics or limiting their functional recovery. Owing to the poor understanding of the biological mechanism of scar formation, there is no constant and effective method for scar control in clinic. Moreover, with the deficiency of adequate animal models, investigators both in China and aboard failed to undertake intensive research on scar formation. As modern cell biology and molecular biology are developing rapidly, the regulatory mechanism of cytokines and growth factors comes into the traditional conception of wound healing. More and more evidences showed the close relationship between wound healing fibroblasts and scar formation. The ability to normal healing depends on a dynamic balance among the components of a complex interactive and interdependent bimolecular network that includes cells, matrix arid a variety of interrelated mediates. From wound to scar, the end of the imbalance is occupied by hypertrophic healing process. To understand why, when or how this imbalance...