Expression Of Glucocortiod Receptor Isoforms In Peripheral Blood Mononuclear Cells From Patients With Myasthenia Gravis Affects The Therapeutic Result Of Glucocorticoid

Backgrounds:Myasthenia gravis (MG) is an autoimmune disease. Glucocorticoid is one of the most important drug in treatment of MG. It is well known that the action is mediated through high affinity binding of GC to the glucocorticoid receptor (GR). It is necessary to explore the function of GR and its relations to GC efficacy. It is well known that alternative splicing of the human glucocorticoid receptor (hGR) primary transcript produces two highly homologous protein isoforms, termed hGRα and hGRβ. The expression of hGR α and hGR β is related with the therapeutic effect of glucocorticoid. But the results always disagree and no conclusion is widely accepted by the others.MG is mainly mediated by the effect of the acetylcholine receptor antibody (AChRAb) against acetylcholine receptor (AChR) on the postsynaptic membrane of the neuromuscular junction (NMJ). Investigation on the relationship of GR and GC sensitivity in MG might break through the clouds of GC function and mechanism in other diseases. There have no detailed data about GR isoforms and their relations to GC efficacy in MG patients given in the literatures till now. The potential role of the hGR isoforms in the regulation of target cell sensitivity to GC prompted us to further evaluate their effect in MG.