Clinical Significance Of Urinary Type Ⅰ Collagen Cross-Linked N-Telopeptides In Bone Metastases Neoplasm

Objective To measure and analyse the significance of urinary type I collagen cross-linked N-telopeptides(uNTX) in the evaluation of prognosis, response to therapy of bone metastatic neoplasms.Methods Subjects were divided into 3 groups.Group A is composed of 35 healthy adult people.Group B is composed of 35 primary tumor patients without bone metastatic neoplasms proofed by x-ray or emission computer tomography(ECT).GroupC is composed of 33 patients with bone metastasis proofed by x-ray or ECT. Measurement of uNTX were made by test kit of uNTX, while measurement of activity of serum alkaline phosphatases(AKP)and calcium concentration were made.Result There were no significant difference of uNTX between Group A and Group B(p>0.05).There were significant difference of uNTX between Group A and Group B,Group C (p<0.01).There were significant difference of uNTX between pretherapy and posttherapy. The rising rate of uNTX,AKP and plasma calcium concentration was 85%, 55%å’ŒP 45 %.Conclusions UNTX is a specifically sensitive maker of bone collagen turnover. UNTX has positive correlation with bone metastasis neoplasms. It is marked high while patients have extensive bone collagen breakdown and more sensitive than activity of serum AKP and plasma calcium concentration. It...