Study Of Somatostatin As Internal Protective Factor In Enlargement Of Systemic Inflammatory Response

Background and aimsMultiple organ dysfunction syndrome(MODS) is a major cause of morbidity and mortality in intensive care units. The most common cause of death in the intensive care unit accounting for as much as 50% mortality. MODS have been demonstrated to result from the imbalance between inflammatory response system, composed of cytokines, inflammatory mediators and cells, and the internal anti-inflammatory system.Inflammatory cells undoubtedly exert pivotal role in inflammatory response system. PMN, one of the most important inflammatory cells, functions throughout the initiation, progression and resolution of inflammation. Neutrophils are constantly produced in the bone marrow and therefore a similar number of PMN are required to die within a defined time period in order to keep cellular homeostasis under physiologic conditions. In the normal inflammatory reaction, PMNs undergo apoptosis after finishing the task of killing bacteria, and then are recognized and digested by macrophage and tissue cells without causing secondary injury to tissues. During homeostasis neutrophil granulocytes have a relatively short life span, but under inflammatory conditions the life span increases drastically leading to a systemic increase in PMN numbers. However, it has become apparent that inappropriate activation of...