The Correlative Investigation Between Multi Slice CT Perfusional Imaging And Angiogenesis In Hepatocellular Carcinoma Induced By Hypoxia Inducible Factor-1α

Part oneThe clinical significance of angiogenesis in Hepatocellular carcinoma induced by hypoxia inducible factor-1αPurpose: To investigate the clinical significance of angiogenesis in Hepatocellular carcinoma induced by hypoxia inducible factor-1α . Methods: Positive expression of hypoxia inducible factor-1α (HIF-1 α )and vascular endothelial growth factor(VEGF) protein in 34 cases Hepatocellular carcinoma and 11 cases hepatic hemangioma and surrounding normal hepatic tissue were investigated with SP immunohistochemistry. Microvessel density (MVD) were determined by anti-CD34 immunostaining. Results: Positive expression of hypoxia inducible factor-1α and vascular endothelial growth factor protein in hepatocellular carcinoma were significantly higher than that of hepatic hemangioma(p<0.05). Positive expression of hypoxia inducible factor-1α and vascular endothelial growth...