The Pathogenesis Study On The Extracellular Matrix In Postmenopausal Osteoporosis

Osteoporosis (OP) is referred to as a systemic bone disease characterized by a decrease of bone mass, microstructure, and function, and resulting in an increased risk of fractures. Postmenopausal osteoporosis, which induced by the decrease of estrogen, is one of the most severe osteoporosis. It has been given great attention for its high morbidity and severe consequence. The expenses for medical treatment of osteoporosis have been gradually increased in the developed countries. In our country, osteoporosis is threatening to the health of more and more middle and old aged people. In order to effectively prevent and cure osteoporosis, the pathogenesis of OP must be explored.The study on the pathology of osteoporosis primarily focused on the calcium homeostasis and the pathophysiological profile of hormones regulating bone metabolism. The postmenopausal estrogen deficiency may also play a role in the pathogenesis of osteoporosis. In recent years, much attention has also been given to factors and proteins in the organic bone matrix, some of which are considered to play a crucial role in the induction of bone formation and presumably in bone remodeling. Type I collagen comprises 90% of the organic matrix of bone and gives to the character of stability and plasticity of bone. It provides the scaffold for mineralization and is responsible for the high tensile strength of bone tissue. The study on the collagenous bone matrix is an important means to reveal the pathogenesis of osteoporosis. Thus the changes of the collagenous bone matrix in postmenopausal osteoporosis was explored by picrosirius-polarization, in...