The Study On Relationship Between Genetic Factor And Non-and-hyporesponsiveness To Hepatitis B Vaccine

Hepatitis B is one of the severe infectious diseases affecting humans. It is estimated 300 million carriers of hepatitis B virus (HBV) worldwide. Hepatitis B vaccination has been proved to be highly effective in preventing HBV infection. But some studies have showed that about 10% vaccinees failed to mount a measurable response or did not develop protective levels of antibody after intramuscular injection with three doses of plasma-derived hepatitis B vaccine who are called non-and-hyporesponders. These persons are actually not protected by vaccination and in high risk of HBV infection. Furthermore, chronic HBsAg carriers can induce cirrhosis and primary hepatocellular carcinoma. In this study, by comparing HBV infection rate under natural state and anti-HBs level after inoculation in the first degree relatives of non-and-hyporesponders and hyperresponders, and human leucocyte antigen (HLA) in non-and-hyporesponders and hyperresponders, the relationship between genetic factor and non-and-hypores-ponsiveness was assessed and further information about evaluating the efficacy on hepatitis B vaccine and its inoculation strategy was available.In October 1994, 634 primary school students in the suburb of Xi'an, aged 5-14 years, were inoculated with three doses of hepatitis B vaccine according to 0, 1,2 schedule (the second...