Study On Model Of Endothelium-Dependent Vasodilatation And Potassium Channels On Smooth Muscle Cells

Vascular smooth muscle tone is controlled by endothelial relaxing factors such as nitric oxide(NO), prostacyclin(PGI₂) and endothelium-dependent hyperpolarizing factor(EDHF) or cytochrome P-450 metabolites. In addition, the endothelium can synthesize endothelium-dependent vasoconstrictors(EDCF) such as the peptide endothelin-l(ET-l), superoxide anions(O^2-) and thromboxane (TXA2). The balance between EDRP and EDCF under physiological condition helps to obtain normal vessel tension ,the blood pressure and organ blood flow, otherwise endothelium dysfunction occurs resulting in cardiovascular diseases, such as Hypertension, Myocardial ischemia, HPV and so on. It is of significant theoretical and practical importance to find an effective compound to improve the endothelium dysfunction.(一) Increased contribution of the L-arginine-nitric oxide pathway in the aorta of mice lacking the cytoskeleton protein gene VimentineThe release of endothelial vasoactive factors can be stimulated not only by hormones, neuromediators or platelet products, but also by mechanical factors such as shear stress caused by physiological blood flow.Endothelial cytoskeletal proteins are involved in the mechanotranduction of flow-induced release of nitric oxide (NO). Vimentine, an intermediate class III filament, is sensitive to both mechanical stress and shear forces. Recently,...