The Applying Of Small Intestinal Submucosa In Tracheoplasty In A Rabbit Model For Tracheal Defect And Culture Of Tracheal Ciliated Epithelial Cells In Vitro

After resection of laryngotracheal cicatricial stenosis, the leaved defect remain a challenge for laryngotracheal surgery. The problems need to solve on laryngotracheal functional rehabilitation including: regeneration and reparation of laryngotracheal epithelium, prevention scar hyperplasy, reparation of laryngotracheal cartilage scaffold and studies on tissue-engineering laryngotracheal. The key to success for severe tracheal defects reparation is to widen laryngotracheal lumen using autologous grafts, allogenic grafts and artificial stents. Despite of its superiority, there is no deny that autografting takes risk of adding wounds and the source of grafts is limited. Thus, laryngotracheal reconstruction is still longing for further research on allograft and...