Changes In The Levels Of Specific IgE, IgG Antibodies, And The Expressions Of CD63, CD203c On Basophils In Patients With Penicillins Allergy

Allergic reactions to penicillins are the most common causes of adverse drug reactions mediated by specific immunological mechanisms. A prospective international study was performed to determine the incidence of allergic reactions, penicillins drug accounted for approximately 75% of fatal anaphylactic cases each year. It is important to elucidate the mechanisms of allergic reaction to penicillins and improve the diagnostic methods.It is generally believed that certain allergic reactions to penicillin belong to Type I hypersensitivity reactions that are mediated by specific IgE antibody. Penicillin intradermal testing is a well-established method to evaluate current penicillin allergic status in China. The advantages of the method is quickenss, sensitiveness, reproducibility, inexpensiveness, and can be performed by almost anybody. Its disadvantages include difficulties related to standardization of the method and the solutions used for testing, and variations that may be seen in results from different operators as well as risks in patients with hypersensitivity reaction. A negative result does not exclude hypersensitivity and positive results sometimes are observed in normal control. There is a need for in vitro tests which can replace the skin tests.The role of IgG antibodies in inducing or modifying allergic reactions to penicillins has not been sufficiently clarified. It maybe related to IgG subclasses. Four subclasses...