The Antitumor Activity Of Exosomes Derived From Human Umbilical Cord Blood Dendritic Cells And Human Gastric Carcinoma BGC823 Cell Line

Human gastric carcinoma is one of the common malignant tumor threatened human health. The conventional treatments are always inefficient. Biotherapy, especially tumor vaccine has brought new hopes for many patients suffered from malignant tumor and have become one of the focuses of tumor treatment and studies. Indeed, vaccines may prove effective for the treatment of cancer. The numerous published reports have shown that vaccination of cancer patients with killed tumor cells, tumor cell lysates or tumor antigen proteins, peptides or DNA administered with cytokines or adjuvants can produce immunologic and clinical responses. However, the immune responses to these vaccines are often weak, and clinical responses are rarely complete and long lasting.Dendritic cells(DCs) are the most potent professional antigen-presenting cells and the only ones capable of inducing primary cytotoxic immune responses and activating na(?)ve T cells. Dendritic cells (DCs) contain MHC-I, MHC-II, and other accessory molecules(CD80, CD86)...