Expression Of TSP-1/TGF-β1 In Pituitary Adenomas And TSP-1 Induce Cell Apotosis In Vitro

PART IEXPRESSION AND ROLE OF TSP-1, CD36, TGF-β1IN PITUITARY ADENOMASObjective Thrombospondin-1 (TSP-1), a 450 kDa trimeric molecule glycoprotein, has been implicated in tumor invasion, angiogenesis. TSP1 has been reported to induce endothelial cell apoptosis in vitro and to downregulate neovascularization in vivo. By binding to transmembrane receptor CD36, thrombospondin-1 inhibits migration and induces apoptosis in in micro vessel endothelial cells and consequently inhibits angiogenesis. That effect can not be decreased by inhibited the activation of TGF-β1. For a specific tumor, whether TSP overexpression promotes or inhibits malignancy could be at least partially dependent on the concentration of TGF-pi at the tumor site.This part aimed to explore the expression of thrombospondin-1 (TSP-1), Transforming Growth Factor-β1 (TGF-β1), CD36 in pituitary adenomas and investigate the relationships between the expression and the factors such as invasiveness, recrudescence, size, sex and hypotype of hormone in adenomas.Method The mRNA expression of TSP-1,TGF-β1,CD36 in 52 surgical specimens (24invasive cases; 28 noinvasive cases)of pituitary adenomas was...