Experimental Study On Relationship Of Myocardial ICAM-1 Expression And Apoptosis As Well As Drugs' Interference In ICAM-1 Expression In Viral Myocarditis

Background and objectives:Viral myocarditis(VM) is mostly caused by infection of enteroviruses (especially Coxsackieviruses). The main histopathologic changes are degeneration and necrosis of myocardiocytes, infiltration of inflammatory cells and fibrosis. The pathogenesis of VM is not demonstrated completely and no specific therapy is found. The incidence of VM has a tendency to increase in recent years and studies on its pathogenesis are being carried out. Present researchs reveal that viral replication, inflammatory media, apoptosis, endothelial dysfunction, immune imbalance and many other factors are related with the development, progress and prognosis of VM, and there are complex relations among these factors. It' s important for understanding pathogenesis and guiding treatment to explore the relations among these factors in VM. Intercellular adhesion molecule-1 (ICAM-1), a representative of adhesion molecules, joins in cell mediated immunoreaction through promoting adhesion between immune cells and target cells. Pathologic apoptosis is involved in the pathogenesis of VM. Earlier studies confirmed that cell mediated immunoreaction may induce apoptosis and necrosis. However, the relationship of myocardial ICAM-1 expression to apoptosis has not been revealed. With murine VM model, this study was to find out the changes...