Clinical And Pathological Relationship Between TNF-α And Henoch-Sch(?)nlein Purpura Nephritis In Children

Backgrounds Henoch-Schonlein purpura (HSP), termed as Henoch-Schonlein purpura nephritis (HSPN) when a renal lesion was found, is the most common systemic vacuities affecting children with whose pathogenesis remaining poorly understood as yet. Generally it is believed to be a circulating immune complex disease induced by IgA-contained immune complexes deposition, whereas investigations in recent years on experimental IgA nephritis showed IgA-contained immune complexes deposition was not the only contributor to renal lesions, proinflammatory cytokine such as TNF-α may also be responsible for the damage of the kidney. Reports recently showed TNF-a may be involved in the pathogenesis suggested by a increased expression of TNF-α in acute stage, decrease in remission in serum, urine and skin suffered from damage in HSP, and higher in subjects with damage in kidney(evaluated by changes of urine routine) than that in those without renal damage. Presently only changes of TNF-α in body fluid and its correlation with proteinuria and haematuria were observed ,whereas there is not evidence concerned to diagnose the disease pathologically and...