Transplantation Of Neural Stem Cells Derived From Bone Marrow Stromal Cells With GDNF For Treatment Of Spinal Cord Injury In Rat

Spinal cord injury (SCI) is a kind of extremely severe damage. It results in the high disability rate and mortality. The traditional therapy of spinal cord injury usually included spine fracture-dislocation stabilization; relieve spinal cord compression, symptom therapy and rehabilitative treatment. Recently, following development of study of neuro-pathophysiology and neuro-auxology, the transplantation of nervous tissue and cells as a new therapy method is gradually being applicated to the treatment of spinal cord injury, and some satisfying progress were found during the therapy.The bone marrow stromal cells (BMSCs ) are a part of bone marrow hemopoietic stem cells. It wAS confirmed recently that in certain culture conditions, BMSCs can differentiate into a variety of cells, for instance, mesenchymal cell, fibroblast, osteoblast, chondrocyte, adipocyte muscle Cells, endothelial cell, neuron, and glial cell etc. The multipotential of BMSC and its ability of differentiate into nerve cell, offers a new source of neural stem cells, and also provide a new idea for solve the shortage of "self- neural stem cells" as one of transplantation project cells.Glial cell line-derived neurotrophic factor (GDNF), a member of transforming growth factor (TGF) super-family trophic factor, is a new kind of neurotrophic factor, which was extracted and purified from B49 cells of adult rats by Lin et al in 1993.