Changes Of Morphology, Function, Receptor, Growth And Apoptosis Related Factors In Rats With Partial Bladder Outlet Obstruction

More than 60% of males older than 60 years of age have urinary bladder outlet obstruction secondary to benign prostatic hypertrophy . Bladder outlet obstruction causes significant morbidity, including irritative voiding symptoms, voiding difficulty and even urinary retention with or without detrusor failure. Levin et al in their pioneering studies have divided the bladder's progressive response to partial outlet obstruction into three phases: ( a) an initial response during which substantial alterations in bladder mass, pharmacology, and physiology occur ; ( b) a compensated phase, characterized by a stable bladder mass and stable (or augmented) contractility; and ( c) a decompensated phase characterized by a progressive deterioration in contractile and functional status. The change of morphology and function status, the modulation of neurotransmitter receptor and the alteration of growth factor and the balance of proliferation and apoptosis may play an important role in the progression of obstructed bladder. A better understanding of the molecular biology of partial bladder outlet obstruction may result in the ability to reverse the cascade of events that lead to irreversible decompensation, we systematically investigate the morphological and molecular changes in the obstructed bladder during different phase.The first part: the morphological and function changes after partial bladder outlet obstruction in the ratWe build the animal model of partial bladder outlet obstruction and divided...